Genetics and Chronic Kidney Disease

Nicholette D. Palmer; Fiona E. Karet Frankl; Etty Kruzel-Davila; Barry I. Freedman

doi:10.1016/b978-0-12-815876-0.00025-5

Genetics and Chronic Kidney Disease

Nicholette D. Palmer
, Fiona E. Karet Frankl
, Etty Kruzel-Davila
, Barry I. Freedman

Wake Forest University
University of Cambridge
Technion-Israel Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Several genes associated with the development of chronic glomerular and tubulointerstitial kidney diseases have been detected. Recent developments include an improved understanding of potential mechanisms involved in nondiabetic glomerulosclerosis, including apolipoprotein L1 gene (APOL1)-associated nephropathy, as well as autosomal dominant tubulointerstitial kidney disease. The identification of genes associated with diabetic kidney disease has proven more challenging. Nephropathy susceptibility genes are changing the classification of common complex kidney diseases, offering new insights into pathogenesis and providing hope for novel treatments. This chapter reviews genetic associations and mechanisms of injury in diabetic and nondiabetic glomerular and tubulointerstitial kidney diseases.

Original language	English
Title of host publication	Chronic Renal Disease
Publisher	Elsevier
Pages	375-396
Number of pages	22
ISBN (Electronic)	9780128158760
ISBN (Print)	9780128158777
DOIs	https://doi.org/10.1016/b978-0-12-815876-0.00025-5
State	Published - 1 Jan 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apolipoprotein L1 gene (APOL1)
Diabetic kidney disease
Focal segmental glomerulosclerosis (FSGS)
Genetics
Podocin gene (NPHS2)
Steroid-resistant nephrotic syndrome
Tubulointerstitial nephropathy

Access to Document

10.1016/b978-0-12-815876-0.00025-5

Cite this

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abstract = "Several genes associated with the development of chronic glomerular and tubulointerstitial kidney diseases have been detected. Recent developments include an improved understanding of potential mechanisms involved in nondiabetic glomerulosclerosis, including apolipoprotein L1 gene (APOL1)-associated nephropathy, as well as autosomal dominant tubulointerstitial kidney disease. The identification of genes associated with diabetic kidney disease has proven more challenging. Nephropathy susceptibility genes are changing the classification of common complex kidney diseases, offering new insights into pathogenesis and providing hope for novel treatments. This chapter reviews genetic associations and mechanisms of injury in diabetic and nondiabetic glomerular and tubulointerstitial kidney diseases.",

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AU - Karet Frankl, Fiona E.

AU - Kruzel-Davila, Etty

AU - Freedman, Barry I.

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KW - Diabetic kidney disease

KW - Focal segmental glomerulosclerosis (FSGS)

KW - Genetics

KW - Podocin gene (NPHS2)

KW - Steroid-resistant nephrotic syndrome

KW - Tubulointerstitial nephropathy

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Genetics and Chronic Kidney Disease

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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