Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity

M. P. Winthereik; L. Lundberg; J. V. Spärck; T. Katzenstein; D. Sompolinsky

doi:10.1111/j.1398-9995.1992.tb05096.x

Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity

M. P. Winthereik
, L. Lundberg
, J. V. Spärck
, T. Katzenstein
, D. Sompolinsky

University of Copenhagen
Statens Serum Institut

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high‐asthma strain (IMM/S 209) and one low‐asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains ‐ one high‐asthma strain (IMM/S 740) and one low‐asthma strain (IMM/R 201–16) – maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)₃ the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA). 1992 Munksgaard

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	47
Issue number	2PART1
DOIs	https://doi.org/10.1111/j.1398-9995.1992.tb05096.x
State	Published - Apr 1992
Externally published	Yes

Keywords

(strains of) guinea pigs
asthma
blood eosinophilia
eosinophilic granulocyte

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10.1111/j.1398-9995.1992.tb05096.x

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title = "Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity",

abstract = "Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high‐asthma strain (IMM/S 209) and one low‐asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains ‐ one high‐asthma strain (IMM/S 740) and one low‐asthma strain (IMM/R 201{\textendash}16) {\textendash} maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3 the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA). 1992 Munksgaard",

keywords = "(strains of) guinea pigs, asthma, blood eosinophilia, eosinophilic granulocyte",

author = "Winthereik, \{M. P.\} and L. Lundberg and Sp{\"a}rck, \{J. V.\} and T. Katzenstein and D. Sompolinsky",

year = "1992",

month = apr,

doi = "10.1111/j.1398-9995.1992.tb05096.x",

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AU - Winthereik, M. P.

AU - Lundberg, L.

AU - Spärck, J. V.

AU - Katzenstein, T.

AU - Sompolinsky, D.

PY - 1992/4

Y1 - 1992/4

N2 - Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high‐asthma strain (IMM/S 209) and one low‐asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains ‐ one high‐asthma strain (IMM/S 740) and one low‐asthma strain (IMM/R 201–16) – maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3 the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA). 1992 Munksgaard

AB - Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high‐asthma strain (IMM/S 209) and one low‐asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains ‐ one high‐asthma strain (IMM/S 740) and one low‐asthma strain (IMM/R 201–16) – maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3 the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA). 1992 Munksgaard

KW - (strains of) guinea pigs

KW - asthma

KW - blood eosinophilia

KW - eosinophilic granulocyte

UR - https://www.scopus.com/pages/publications/0026511807

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JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 2PART1

ER -

Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity

Abstract

Keywords

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