TY - JOUR
T1 - Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity 2. A genetic study of spontaneous and immunization‐induced eosinophilia
AU - Winthereik, M. Ploug
AU - Spärck, J. V.
AU - Lundberg, L.
AU - Sompolinsky, D.
PY - 1992/4
Y1 - 1992/4
N2 - Ploug Winthereik M, Spärck JV, Lundberg L, Sompolinsky D. Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity. 2. A genetic study of spontaneous and immunization‐induced eosinophilia. In 4 inbred strains of guinea pig the tendency to develop peripheral high‐eosinophilia was shown to be genetically controlled. The development of eosinophilia with age and following immunization was examined in high‐ and low‐eosinophilic parental strains, in F1‐hybrids and in backcross offspring. The results show that probably only one or a very few segregating genes control eosinophilia, and they also indicate that different genes are involved in the determination of spontaneous (age‐related) and immunization‐induced eosinophilia.
AB - Ploug Winthereik M, Spärck JV, Lundberg L, Sompolinsky D. Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity. 2. A genetic study of spontaneous and immunization‐induced eosinophilia. In 4 inbred strains of guinea pig the tendency to develop peripheral high‐eosinophilia was shown to be genetically controlled. The development of eosinophilia with age and following immunization was examined in high‐ and low‐eosinophilic parental strains, in F1‐hybrids and in backcross offspring. The results show that probably only one or a very few segregating genes control eosinophilia, and they also indicate that different genes are involved in the determination of spontaneous (age‐related) and immunization‐induced eosinophilia.
KW - (strains of) guinea pigs
KW - blood eosinophilia
KW - eosinophilic granulocyte
KW - genetics
UR - http://www.scopus.com/inward/record.url?scp=0026684372&partnerID=8YFLogxK
U2 - 10.1111/j.1398-9995.1992.tb00958.x
DO - 10.1111/j.1398-9995.1992.tb00958.x
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C2 - 1514667
AN - SCOPUS:0026684372
SN - 0105-4538
VL - 47
SP - 164
EP - 167
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 2
ER -