Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity

M. P. Winthereik, L. Lundberg, J. V. Spärck, T. Katzenstein, D. Sompolinsky

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high‐asthma strain (IMM/S 209) and one low‐asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains ‐ one high‐asthma strain (IMM/S 740) and one low‐asthma strain (IMM/R 201–16) – maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3 the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA). 1992 Munksgaard

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume47
Issue number2PART1
DOIs
StatePublished - Apr 1992
Externally publishedYes

Keywords

  • (strains of) guinea pigs
  • asthma
  • blood eosinophilia
  • eosinophilic granulocyte

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