Genetic and peripheral markers of the oxytocin system and parental care jointly support the cross-generational transmission of bonding across three generations

Takeo Fujiwara, Omri Weisman, Manami Ochi, Kokoro Shirai, Kenji Matsumoto, Emiko Noguchi, Ruth Feldman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Human and animal research indicates that oxytocin (OT) plays a key role in the cross-generational transmission of parental bonding, and human studies suggest that allelic variations on the oxytocin receptor gene (OXTR) and circulating OT levels interact with patterns of parental care to shape children's social-affiliative competencies. Yet, no study to date has tested the joint contribution of OT and parental care across three generations. Methods: The study included 345 participants comprising 115 family lines of grandmothers, mothers, and their infants. Salivary OT and allelic variations on the OXTR (rs53576 and rs2254298) and CD38 (rs3796863) single nucleotide polymorphisms (SNPs), which have been previously associated with parental bonding, were assessed in all participants. Parental care was measured from grandmothers to mothers and from mothers to their infants. Results: Mothers receiving parenting characterized by high overprotection from grandmothers showed more rejection toward their infants only when carrying the G allele on the OXTRrs53576 (AG/GG). These mothers of highly overprotective grandmothers also had lower oxytocin levels. Infants who were OXTRrs2254298 A carriers (AA/AG) and whose mothers reported more rejection toward their infants had higher oxytocin levels. Grandmothers receiving higher overprotection from great-grandmothers showed poorer parenting style compared to grandmothers experiencing lower parental overprotection only when carrying the OXTRrs2254298 GG genotype. Conclusions: Our findings are the first to demonstrate how genetic and peripheral markers on the oxytocin system interact with experienced parenting to shape bonding across three generations. Results have important implications for specifying the biological and behavioral determinants associated with the continuity of adaptive versus maladaptive patterns of attachment across generations.

Original languageEnglish
Pages (from-to)172-181
Number of pages10
JournalPsychoneuroendocrinology
Volume102
DOIs
StatePublished - Apr 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Funding

This work is supported by grants from the Research Development Grant for Child Health and Development from the National Center for Child Health and Development (24-12). Ruth Feldman is supported by the Simms/Mann Chair for Developmental Neuroscience at IDC Herzlia .

FundersFunder number
IDC Herzlia
National Center for Child Health and Development24-12
Japan Society for the Promotion of Science15KT0007

    Keywords

    • Attachment
    • CD38
    • Cross-generational transmission
    • OXTR
    • Oxytocin
    • Parenting
    • Three generation

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