Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules

C. Cohen; G Denkberg; D Segal; Y Reiter

Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules

C. Cohen
, G Denkberg
, D Segal
, Y Reiter

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a desirable target for novel approaches in immunotherapy because of their highly restricted fine specificity. Expression of specific peptides in complex with MHC class I molecules on cells was shown to be associated with cancer and autoimmune disorders (1–8). For example, human melanomas express tumor-specific peptides that are presented to the immune

Original language	American English
Title of host publication	Recombinant Antibodies for Cancer Therapy: Methods and Protocols
Editors	Martin Welschof, Jürgen Krauss
Publisher	Humana Press
Pages	269-282
ISBN (Print)	978-1-59259-334-7
State	Published - 2003

Publication series

Name	Methods in Molecular Biology
Volume	207

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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abstract = "Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a desirable target for novel approaches in immunotherapy because of their highly restricted fine specificity. Expression of specific peptides in complex with MHC class I molecules on cells was shown to be associated with cancer and autoimmune disorders (1–8). For example, human melanomas express tumor-specific peptides that are presented to the immune",

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Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules. / Cohen, C.; Denkberg, G; Segal, D et al.
Recombinant Antibodies for Cancer Therapy: Methods and Protocols. ed. / Martin Welschof; Jürgen Krauss. Humana Press, 2003. p. 269-282 (Methods in Molecular Biology; Vol. 207).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules

AU - Cohen, C.

AU - Denkberg, G

AU - Segal, D

AU - Reiter, Y

PY - 2003

Y1 - 2003

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AB - Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a desirable target for novel approaches in immunotherapy because of their highly restricted fine specificity. Expression of specific peptides in complex with MHC class I molecules on cells was shown to be associated with cancer and autoimmune disorders (1–8). For example, human melanomas express tumor-specific peptides that are presented to the immune

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M3 - Chapter

SN - 978-1-59259-334-7

T3 - Methods in Molecular Biology

SP - 269

EP - 282

BT - Recombinant Antibodies for Cancer Therapy: Methods and Protocols

A2 - Welschof, Martin

A2 - Krauss, Jürgen

PB - Humana Press

ER -

Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules

Abstract

Publication series

UN SDGs

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