General and abdominal obesity operate differently as influencing factors of fracture risk in old adults

Xiao Wei Zhu; Ke Qi Liu; Cheng Da Yuan; Jiang Wei Xia; Yu Qian; Lin Xu; Jian Hua Gao; Xiao Li Rong; Guo Bo Chen; David Karasik; Shu Yang Xie; Hou Feng Zheng

doi:10.1016/j.isci.2022.104466

General and abdominal obesity operate differently as influencing factors of fracture risk in old adults

Xiao Wei Zhu, Ke Qi Liu, Cheng Da Yuan, Jiang Wei Xia, Yu Qian, Lin Xu, Jian Hua Gao, Xiao Li Rong, Guo Bo Chen, David Karasik, Shu Yang Xie, Hou Feng Zheng

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

To infer the causality between obesity and fracture and the difference between general and abdominal obesity, a prospective study was performed in 456,921 participants, and 10,142 participants developed an incident fracture with follow-up period of 7.96 years. A U-shape relationship was observed between BMI and fracture, with the lowest risk of fracture in overweight participants. The obesity individuals had higher fracture risk when BMD was adjusted, and the protective effect of moderate-high BMI on fracture was mostly mediated by bone mineral density (BMD). However, for abdominal obesity, the higher WCadjBMI (linear) and HCadjBMI (J-shape) were found to be related to higher fracture risk, and less than 30% of the effect was mediated by BMD. By leveraging genetic instrumental variables, it provided additional evidences to support the aforementioned findings. In conclusion, keeping moderate-high BMI might be of benefit to old people in terms of fracture risk, whereas abdominal adiposity might increase risk of fracture.

Original language	English
Article number	104466
Journal	iScience
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.isci.2022.104466
State	Published - 17 Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Funding

This work was supported by the Chinese National Key Technology R&D Program , Ministry of Science and Technology ( 2021YFC2501702 ). This work was also supported by the joint program of National Natural Science Foundation of China (NSFC) and Israel Science Foundation (ISF) ( NSFC#32061143019 and ISF#3408/20 ). The funders had no role in any step of the present study, from study protocol to manuscript preparation. We thank the UK Biobank database (Application 41376) and the GEnetic Factors for OSteoporosis (GEFOS) Consortium. We also thank the High-Performance Computing Center at Westlake University for the facility support and technical assistance.

Funders	Funder number
Chinese National Key Technology R&D Program
National Natural Science Foundation of China
Ministry of Science and Technology of the People's Republic of China	2021YFC2501702
Israel Science Foundation	32061143019, 3408/20

Keywords

Health sciences
Obesity medicine
Risk factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.isci.2022.104466

Cite this

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title = "General and abdominal obesity operate differently as influencing factors of fracture risk in old adults",

abstract = "To infer the causality between obesity and fracture and the difference between general and abdominal obesity, a prospective study was performed in 456,921 participants, and 10,142 participants developed an incident fracture with follow-up period of 7.96 years. A U-shape relationship was observed between BMI and fracture, with the lowest risk of fracture in overweight participants. The obesity individuals had higher fracture risk when BMD was adjusted, and the protective effect of moderate-high BMI on fracture was mostly mediated by bone mineral density (BMD). However, for abdominal obesity, the higher WCadjBMI (linear) and HCadjBMI (J-shape) were found to be related to higher fracture risk, and less than 30% of the effect was mediated by BMD. By leveraging genetic instrumental variables, it provided additional evidences to support the aforementioned findings. In conclusion, keeping moderate-high BMI might be of benefit to old people in terms of fracture risk, whereas abdominal adiposity might increase risk of fracture.",

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AU - Xu, Lin

AU - Gao, Jian Hua

AU - Rong, Xiao Li

AU - Chen, Guo Bo

AU - Karasik, David

AU - Xie, Shu Yang

AU - Zheng, Hou Feng

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General and abdominal obesity operate differently as influencing factors of fracture risk in old adults

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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