Gene expression profiling in the study of the pathogenesis of systemic lupus erythematosus

Xiaoping Qing, Chaim Putterman

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a complex pathogenesis involving multiple genetic and environmental contributions. DNA microarray technology has recently been applied to unravel some of this complexity through genomewide profiling. Early studies using microarray analysis of peripheral blood mononuclear cells (PBMCs) from SLE patients revealed dysregulation of inflammatory cytokines, chemokines, and immune response-related genes, as well as genes involved in apoptosis, signal transduction, and the cell cycle. More recently, using arrays containing many more genes, 4 independent research groups have found that interferon (IFN)-regulated genes are highly overexpressed in the peripheral blood and kidney glomeruli of SLE patients, supporting a crucial role for interferon in SLE. Future studies focusing on target tissues or organs in lupus, including the kidney, may further contribute to our understanding of lupus pathogenesis while providing new targets for therapy.

Original languageEnglish
Pages (from-to)505-509
Number of pages5
JournalAutoimmunity Reviews
Volume3
Issue number7-8 SPEC.ISS.
DOIs
StatePublished - Nov 2004
Externally publishedYes

Bibliographical note

Funding Information:
Dr. Putterman is supported by NIH grants RO1 AR486912 and PO1 AI51392, a Target Identification in Lupus Award from the Alliance for Lupus Research/Arthritis Foundation and a Hulda Irene Duggan Arthritis Investigator Award from the Arthritis Foundation.

Funding

Dr. Putterman is supported by NIH grants RO1 AR486912 and PO1 AI51392, a Target Identification in Lupus Award from the Alliance for Lupus Research/Arthritis Foundation and a Hulda Irene Duggan Arthritis Investigator Award from the Arthritis Foundation.

FundersFunder number
Alliance for Lupus Research/Arthritis Foundation
Hulda Irene Duggan Arthritis
National Institutes of HealthRO1 AR486912
National Institute of Allergy and Infectious DiseasesP01AI051392
Arthritis Foundation

    Keywords

    • DNA microarray
    • Gene expression
    • Interferon
    • Systemic lupus erythematosus (SLE)

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