Gene expression meta-analysis reveals the up-regulation of CREB1 and CREBBP in Brodmann Area 10 of patients with schizophrenia

Shay Ohayon, Assif Yitzhaky, Libi Hertzberg

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13 Scopus citations


Cognitive impairments characterize individuals with schizophrenia, and are correlated to the patients’ functional outcome. The transcription factor Cyclic AMP-responsive element-binding protein-1 (CREB1) is involved in learning and memory processes. CREB1 and both CREB-binding protein (CREBBP) and E1A Binding Protein P300 (EP300), co-activators of CREB1, have been associated with schizophrenia. We performed a systematic meta-analysis of CREB1, CREBBP and EP300 differential expression in post mortem Brodmann Area 10 (BA10) samples of patients with schizophrenia vs. healthy controls, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two microarray datasets met the inclusion criteria (overall 41 schizophrenia samples and 38 controls were analyzed). We detect up-regulation of CREB1 and CREBBP in BA10 samples of patients with schizophrenia, while EP300 wasn't differentially expressed. The integration of two independent datasets and the positive correlation between the expression patterns of CREB1 and CREBBP increase the validity of the results. The up-regulation of CREB1 and its co-activator CREBBP might relate to BA10 altered activation that has been shown in schizophrenia. As BA10 was shown to be involved in the cognitive impairments associated with schizophrenia, this suggests involvement of CREB1 and CREBBP in the cognitive symptoms that characterize the disease.

Original languageEnglish
Article number113311
JournalPsychiatry Research
StatePublished - Oct 2020

Bibliographical note

Publisher Copyright:
© 2020


This work was funded by a 2014 NARSAD Young Investigator Grant from the Brain & Behavior Foundation and the Leir Charitable Foundation

FundersFunder number
Brain & Behavior Foundation
Leir Charitable Foundation
National Alliance for Research on Schizophrenia and Depression


    • Brodmann Area 10 (BA10)
    • CREB1
    • Gene expression
    • Meta-analysis
    • Schizophrenia


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