Gene-diet interactions on bone

Serge Ferrari, David Karasik

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


Osteoporosis is a complex disease, with both environmental and genetic components. Moreover, there are clear suggestions that nutritional and genetic factors interact to influence bone modeling and mineral homeostasis during the years of peak bone mass acquisition, as well as influence bone remodeling and the maintenance of bone mass. Here we review the bases for candidate gene and genome-wide association studies with bone mineral density and fractures, as well as the candidate gene studies that investigated gene-dietary interactions in osteoporosis. These include the VDR, ESR1, and Il-6 gene with vitamin D and/or calcium intake, and Ppar and lipids intake. Notably, few genome-wide association studies (GWAS) to date have incorporated G*E interactions into the analysis design and this is primarily due to the challenges associated with such an approach. Also, more refined phenotypes than areal bone mineral density (aBMD) are required, with a focus on cellular and molecular processes in bones in response to nutrition. If successful, such genome-wide interaction studies (GWIS) can contribute to better bone health by proposing individualized Recommended Dietary Allowances (RDA) for various nutrients.

Original languageEnglish
Title of host publicationNutrition and Bone Health
PublisherSpringer New York
Number of pages16
ISBN (Electronic)9781493920013
ISBN (Print)9781493920006
StatePublished - 1 Jan 2015

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2015.


  • Bone mineral density
  • Calcium
  • ESR1
  • Genetics
  • Genome-wide associations
  • IL-6
  • Interaction
  • Phenotype
  • VDR
  • Vitamin D


Dive into the research topics of 'Gene-diet interactions on bone'. Together they form a unique fingerprint.

Cite this