Gastric goblet cell carcinoma concurrent with a neuroendocrine tumor

Riham Imam, Ashraf Imam, Karin Atlan, Yoav Mintz, Tawfik khoury, Simona Grozinsky-Galsberg, Kira Oleinikov, Alon J. Pikarsky, Abed Khalaileh

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2 Scopus citations


Goblet cell carcinoma, a tumor that is assumed to originate from crypt base stem cells, is a distinct type of tumor, that occurs typically in the appendix, however, extra-appendiceal locations were also described in few cases. We herein present a unique case of a 48-year-old male with a diagnosis of primary gastric Goblet cell carcinoma that was initially discovered at the time of an endoscopy performed to evaluate an unremitting abdominal pain that was accompanied by remarkable weight loss; four polypoid fragments of the gastric mucosa were sent for histopathologic examination which showed a moderately differentiated goblet cell carcinoma in addition to classical neuroendocrine tumor. Later, laparoscopic D2 total gastrectomy with appendectomy were performed and confirmed the previously mentioned findings along with a normal histopathology of the appendix.

Original languageEnglish
Article number153092
JournalPathology Research and Practice
Issue number9
StatePublished - Sep 2020
Externally publishedYes

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© 2020 Elsevier GmbH


  • Adenocarcinoid
  • Extra-appendiceal
  • Goblet cell carcinoma


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