Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Chinnakkaruppan Adaikkan; Steven J. Middleton; Asaf Marco; Ping Chieh Pao; Hansruedi Mathys; David Nam Woo Kim; Fan Gao; Jennie Z. Young; Ho Jun Suk; Edward S. Boyden; Thomas J. McHugh; Li Huei Tsai

doi:10.1016/j.neuron.2019.04.011

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Chinnakkaruppan Adaikkan
, Steven J. Middleton
, Asaf Marco
, Ping Chieh Pao
, Hansruedi Mathys
, David Nam Woo Kim
, Fan Gao
, Jennie Z. Young
, Ho Jun Suk
, Edward S. Boyden
, Thomas J. McHugh
, Li Huei Tsai

Research output: Contribution to journal › Article › peer-review

348 Scopus citations

Abstract

Chronic application of patterned visual stimulation in neurodegeneration mouse models to entrain gamma oscillations results in preservation of neuronal and synaptic density across multiple brain regions.

Original language	English
Pages (from-to)	929-943.e8
Journal	Neuron
Volume	102
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2019.04.011
State	Published - 5 Jun 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Funding

We thank N. Dedic, A.S. Singer, S. Barker, R.W. Komorowski, K. Abdelaal, M. Murdock, F. Abdurrob, E. Lockshin, R.T. Stott, and the members of L.-H.T. Lab for helpful discussion and suggestions. We thank E. McNamara for mice colony maintenance, A. Del Rosario (Koch Institute for Integrative Cancer Research) for help with mass spectrometry, and A. Watson, T. Ko, M. Saturno-Condon (Koch Institute), and P. Autissier (Whitehead Institute) for help with FACS. C.A. was supported by The JPB Foundation . This work was supported by NIH RF1 AG047661 and RF1 AG054321 to L.-H.T., and grants to L.-H.T. from Halis Family Foundation , The JPB Foundation , and Robert A. and Renee E. Belfer Family Foundation . We thank N. Dedic, A.S. Singer, S. Barker, R.W. Komorowski, K. Abdelaal, M. Murdock, F. Abdurrob, E. Lockshin, R.T. Stott, and the members of L.-H.T. Lab for helpful discussion and suggestions. We thank E. McNamara for mice colony maintenance, A. Del Rosario (Koch Institute for Integrative Cancer Research)for help with mass spectrometry, and A. Watson, T. Ko, M. Saturno-Condon (Koch Institute), and P. Autissier (Whitehead Institute)for help with FACS. C.A. was supported by The JPB Foundation. This work was supported by NIH RF1 AG047661 and RF1 AG054321 to L.-H.T. and grants to L.-H.T. from Halis Family Foundation, The JPB Foundation, and Robert A. and Renee E. Belfer Family Foundation. C.A. and L.-H.T. conceptualized and designed the project. C.A. D.N.-W.K. and P.-C.P. performed stimulation and behavioral experiments. C.A. D.N.-W.K. P.-C.P. A.M. and H.M. performed immunostainings. C.A. P.-C.P. A.M. H.M. and F.G. performed proteomic analysis. C.A. S.J.M. and T.J.M. performed electrophysiology analyses. C.A. H.M. and F.G. performed RNA-sequencing analysis. C.A. and D.N.-W.K. performed western blotting experiments. H.J.S. and E.S.B. provided the tools. All authors interpreted the data. C.A. S.J.M. J.Z.Y. T.J.M. and L.H.T. wrote the manuscript with the input from all authors. L.-H.T. provided the tools and supervised the project. L.-H.T. and E.S.B are scientific co-founders and serve on the scientific advisory board of Cognito Therapeutics.

Funders	Funder number
Halis Family Foundation
National Institutes of Health	RF1 AG054321
National Institute on Aging	RF1AG047661
JPB Foundation	Renee E. Belfer Family Foundation, Robert A.
Robert A. and Renee E. Belfer Family Foundation
Norges Idrettshøgskole

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10.1016/j.neuron.2019.04.011

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title = "Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection",

abstract = "Chronic application of patterned visual stimulation in neurodegeneration mouse models to entrain gamma oscillations results in preservation of neuronal and synaptic density across multiple brain regions.",

author = "Chinnakkaruppan Adaikkan and Middleton, \{Steven J.\} and Asaf Marco and Pao, \{Ping Chieh\} and Hansruedi Mathys and Kim, \{David Nam Woo\} and Fan Gao and Young, \{Jennie Z.\} and Suk, \{Ho Jun\} and Boyden, \{Edward S.\} and McHugh, \{Thomas J.\} and Tsai, \{Li Huei\}",

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Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Abstract

Bibliographical note

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