Abstract
The opportunistic pathogen Pseudomonas aeruginosa causes infections that are difficult to treat by antibiotic therapy. This research article reports on the synthesis of gallium (Ga) doped in carbon (C)-dots (Ga@C-dots) and their antimicrobial activity against free-living P. aeruginosa bacteria. The synthesis of Ga@C-dots was carried out by sonicating molten Ga (for 2.5 h) in polyethylene glycol-400, which acts as both a medium and carbon source. The resultant Ga@C-dots, having an average diameter of 9±2 nm, showed remarkably enhanced antibacterial activity compared with undoped C-dots. This was reflected by the much lower concentration of Ga doped within Ga@C-dots which was required for full inhibition of the bacterial growth. These results highlight the possibility of using Ga@C-dots as potential antimicrobial agents.
| Original language | English |
|---|---|
| Pages (from-to) | 725-730 |
| Number of pages | 6 |
| Journal | International Journal of Nanomedicine |
| Volume | 12 |
| DOIs | |
| State | Published - 23 Jan 2017 |
Bibliographical note
Publisher Copyright:© 2017 Kumar et al.
Funding
The authors wish to express their gratitude and thanks to Prof Gil Goobes and Dr Keren Keinan-Adamsky, Department of Chemistry, Bar Ilan University, for helping with solid-state NMR measurements. MN would like to acknowledge the Adams scholarship for outstanding Ph.D. students, Israel academy of Sciences and Humanity. EB would like to acknowledge the Dyna and Fala Weinstock Foundation for their support. This research was partially supported by the JPI-AMR organization for the NPERDMDR project administered and supported (in part) by grant number 3-11992 from the Chief Scientist Office of the Ministry of Health, Israel.
| Funders | Funder number |
|---|---|
| Dyna and Fala Weinstock Foundation | 3-11992 |
| Bar-Ilan University | |
| Israel Academy of Sciences and Humanities | |
| Ministry of Health, State of Israel |
Keywords
- Antibacterial
- C-dots
- Ga@C-dots
- Gallium
- Pseudomonas aeruginosa
- Sonochemistry