Abstract
Fusions of two different genes could lead to the production of chimeric RNAs, which could be translated into novel fusion (or chimeric) proteins. Fusion proteins often act as oncoproteins and drive cancer development, particularly in leukemia and lymphomas. Fusion proteins modify the existing protein-protein interaction (PPI) networks, which could eliminate some PPIs by removing protein domains in such fusions. This alternation of protein interaction networks could impact the signaling pathways and switch on the cancer-promoting activity that could drive the generation of cancer phenotypes and/or loss of controlled apoptosis. Thus, knowledge of the fusion proteins and their protein interaction networks could facilitate a deeper molecular understanding of cancer development, which could help to design new approaches for cancer therapies. Here, we discuss the structural features of fusion proteins and how they impact the PPI networks in cancers. Further, we discuss how to analyze the fusion protein-mediated alternation of PPI networks in cancers.
| Original language | English |
|---|---|
| Title of host publication | Protein Interaction Networks |
| Editors | Rossen Donev |
| Publisher | Academic Press Inc. |
| Pages | 165-176 |
| Number of pages | 12 |
| ISBN (Print) | 9780323992312 |
| DOIs | |
| State | Published - Jan 2022 |
Publication series
| Name | Advances in Protein Chemistry and Structural Biology |
|---|---|
| Volume | 131 |
| ISSN (Print) | 1876-1623 |
| ISSN (Electronic) | 1876-1631 |
Bibliographical note
Funding Information:We thank the members of the Cancer Genomics and BioComputing of Complex Diseases laboratory for the useful discussions. We thank the Israel Council for Higher Education (CHE) for the PBC Fellowship awarded to Dr. Sumit Mukherjee under the category of outstanding postdoctoral researchers from China and India (2019–21).
Publisher Copyright:
© 2022 Elsevier Inc.
Keywords
- Cancer
- Chimeric RNA
- Fusion gene
- Fusion protein
- PPI
- Precision medicine
