Functionalized Peptide-Based Nanoparticles for Targeted Cancer Nanotherapeutics: A State-of-the-Art Review

Ritika Sharma, Shikha Jyoti Borah, Bhawna, Sanjeev Kumar, Akanksha Gupta, Poonam Singh, Vijay Kumar Goel, Ravinder Kumar, Vinod Kumar

Research output: Contribution to journalReview articlepeer-review


Cancer mortality is increasing at an alarming rate across the globe. Albeit, many therapeutics are available commercially, they are not effective and have no cure up to today. Moreover, the knowledge gap in cancer therapy persists, representing a potential blind spot for the innovation of effective anticancer therapeutics. This review presents an update on current advancements in nanopeptide therapeutics. Herein, a detailed exploration of peptide-functionalized nanoparticles for the development of nanotherapeutics was carried out. Different approaches that include self-assembly nanostructures, solid phase peptide synthesis, ligand exchange, chemical reduction, and conjugation methods for assembling peptides for functionalizing nanodrugs are also highlighted. An outlook on biomedical applications is also reviewed. Additionally, a comprehensive discussion on targeted cancer cell therapy and mechanism of action are provided. The present review reflects the functional novelty of nanodrugs to improve stability, accessibility, bioavailability, and specificity toward cancerous cells. Finally, it summarizes the current challenges and future perspectives on the formulation of these nanodrugs.

Original languageEnglish
Pages (from-to)36092-36107
Number of pages16
JournalACS Omega
Issue number41
StatePublished - 18 Oct 2022
Externally publishedYes

Bibliographical note

Funding Information:
S.J.B. and V.K.G. thank Jawaharlal Nehru University, New Delhi, and Sanganeria Foundation, New Delhi, for financial support, respectively. B. and S.K. thank University Grant Commission and Council of Scientific & Industrial Research (File no. 08/694(0004)/2018-EMR-I), respectively, for the Senior Research Fellowships.

Publisher Copyright:
© 2022 American Chemical Society.


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