Functionalized Graphene Tagged Polyurethanes for Corrosion Inhibitor and Sustained Drug Delivery

Dinesh K. Patel; Sudipta Senapati; Punita Mourya; Madan M. Singh; Vinod K. Aswal; Biswajit Ray; Pralay Maiti

doi:10.1021/acsbiomaterials.7b00342

Functionalized Graphene Tagged Polyurethanes for Corrosion Inhibitor and Sustained Drug Delivery

Dinesh K. Patel
, Sudipta Senapati
, Punita Mourya
, Madan M. Singh
, Vinod K. Aswal
, Biswajit Ray
, Pralay Maiti

Indian Institute of Technology Banaras Hindu University
Homi Bhabha National Institute
Banaras Hindu University

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Surface functionalization of graphene oxide with sulfonate group and subsequent grafting with polyurethane chains leads to the significant improvement in the properties of polymer and modified graphene as a filler. Modification of graphene oxide is revealed through spectroscopy while grafting of polymer chain over sulfonated graphene is confirmed through ¹H NMR and other techniques. Higher order of self-assembly phenomena is observed in nanohybrids as compared to pure polymer through greater interaction between polymer chain and sulfonated graphene. Significant improvement in corrosion inhibition phenomena is observed using nanohybrids at low concentration as compared to pure polymer indicating its superior efficiency as a corrosion inhibitor. Nanohybrids also exhibit better biocompatible nature in lower concentration of filler with considerable sustained release of drug vis-à-vis pure polymer suggest its potential to use as a biomaterial for tissue engineering applications.

Original language	English
Pages (from-to)	3351-3363
Number of pages	13
Journal	ACS Biomaterials Science and Engineering
Volume	3
Issue number	12
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00342
State	Published - 11 Dec 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

Funding

D.K.P. gratefully acknowledges the financial support from CSIR/UGC (17-06/2012 (i) EU-V) New Delhi in form of fellowship. The authors also acknowledge the Science and Engineering Research Board (Grant R&D/SERB/LT/SMST/ 16/17/06) (SERB) & Council for Scientific and Industrial Research, (Grant 02(0074)/12/EMR-II) New Delhi for financial support. The authors gratefully acknowledge Prof. N. Misra, School of Biomedical Engineering IIT (BHU), Varanasi, for providing the spectrophotometer facility. The authors also acknowledge the Central Instrumentation Facility Centre (CIFC) IIT-BHU, Varanasi, for 1H NMR, SEM, and AFM characterization. D.K.P. gratefully acknowledges the financial support from CSIR/UGC (17-06/2012 (i) EU-V) New Delhi in form of fellowship. The authors also acknowledge the Science and Engineering Research Board (Grant R&D/SERB/LT/SMST/16/17/06) (SERB) & Council for Scientific and Industrial Research, (Grant 02(0074)/12/EMR-II) New Delhi for financial support. The authors gratefully acknowledge Prof. N. Misra School of Biomedical Engineering IIT (BHU), Varanasi, for providing the spectrophotometer facility. The authors also acknowledge the Central Instrumentation Facility Centre (CIFC) IIT-BHU, Varanasi, for 1H NMR, SEM, and AFM characterization.

Funders	Funder number
CSIR/UGC
Council for Scientific and Industrial Research	02(0074)/12/EMR-II
Science and Engineering Research Board	R&D/SERB/LT/SMST/16/17/06

Keywords

corrosion inhibitor
drug delivery and biocompatibility
self-assembly
surface modification

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10.1021/acsbiomaterials.7b00342

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abstract = "Surface functionalization of graphene oxide with sulfonate group and subsequent grafting with polyurethane chains leads to the significant improvement in the properties of polymer and modified graphene as a filler. Modification of graphene oxide is revealed through spectroscopy while grafting of polymer chain over sulfonated graphene is confirmed through 1H NMR and other techniques. Higher order of self-assembly phenomena is observed in nanohybrids as compared to pure polymer through greater interaction between polymer chain and sulfonated graphene. Significant improvement in corrosion inhibition phenomena is observed using nanohybrids at low concentration as compared to pure polymer indicating its superior efficiency as a corrosion inhibitor. Nanohybrids also exhibit better biocompatible nature in lower concentration of filler with considerable sustained release of drug vis-{\`a}-vis pure polymer suggest its potential to use as a biomaterial for tissue engineering applications.",

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Functionalized Graphene Tagged Polyurethanes for Corrosion Inhibitor and Sustained Drug Delivery

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Keywords

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