Functionalized gold nanostructures: Promising gene delivery vehicles in cancer treatment

Sanjay Kumar, Anchita Diwan, Parinita Singh, Shikha Gulati, Devanshu Choudhary, Ayush Mongia, Shefali Shukla, Akanksha Gupta

Research output: Contribution to journalArticlepeer-review


Surface-modified gold nanoparticles are recognized as promising gene delivery vehicles in the treatment of cancer owing to their excellent biocompatibility with biomolecules (like DNA or RNA) and their unique optical and structural properties. In this context, this review article focuses on the diverse transfection abilities of the gene to the targeted cell on the basis of different shapes and sizes of gold nanoparticles in order to promote its effective expression for cancer treatment. In addition, recent trends in gold nanoparticle mediated gene silencing, gene delivery, detection and combinatory therapies are highlighted considering their cytotoxic effects on healthy human cells.

Original languageEnglish
Pages (from-to)23894-23907
Number of pages14
JournalRSC Advances
Issue number41
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Royal Society of Chemistry.


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