Functionalized gold nanostructures: Promising gene delivery vehicles in cancer treatment

Sanjay Kumar; Anchita Diwan; Parinita Singh; Shikha Gulati; Devanshu Choudhary; Ayush Mongia; Shefali Shukla; Akanksha Gupta

doi:10.1039/c9ra03608c

Functionalized gold nanostructures: Promising gene delivery vehicles in cancer treatment

Sanjay Kumar, Anchita Diwan, Parinita Singh, Shikha Gulati, Devanshu Choudhary, Ayush Mongia, Shefali Shukla, Akanksha Gupta

University of Delhi

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Surface-modified gold nanoparticles are recognized as promising gene delivery vehicles in the treatment of cancer owing to their excellent biocompatibility with biomolecules (like DNA or RNA) and their unique optical and structural properties. In this context, this review article focuses on the diverse transfection abilities of the gene to the targeted cell on the basis of different shapes and sizes of gold nanoparticles in order to promote its effective expression for cancer treatment. In addition, recent trends in gold nanoparticle mediated gene silencing, gene delivery, detection and combinatory therapies are highlighted considering their cytotoxic effects on healthy human cells.

Original language	English
Pages (from-to)	23894-23907
Number of pages	14
Journal	RSC Advances
Volume	9
Issue number	41
DOIs	https://doi.org/10.1039/c9ra03608c
State	Published - 29 Jul 2019
Externally published	Yes

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Publisher Copyright:
© 2019 The Royal Society of Chemistry.

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AU - Diwan, Anchita

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AU - Gulati, Shikha

AU - Choudhary, Devanshu

AU - Mongia, Ayush

AU - Shukla, Shefali

AU - Gupta, Akanksha

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Functionalized gold nanostructures: Promising gene delivery vehicles in cancer treatment

Abstract

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