Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration

Ohan S. Manoukian; Jiana T. Baker; Swetha Rudraiah; Michael R. Arul; Anthony T. Vella; Abraham J. Domb; Sangamesh G. Kumbar

doi:10.1016/j.jconrel.2019.11.021

Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration

Ohan S. Manoukian, Jiana T. Baker, Swetha Rudraiah, Michael R. Arul, Anthony T. Vella, Abraham J. Domb, Sangamesh G. Kumbar

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.

Original language	English
Pages (from-to)	78-95
Number of pages	18
Journal	Journal of Controlled Release
Volume	317
DOIs	https://doi.org/10.1016/j.jconrel.2019.11.021
State	Published - 10 Jan 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V.

Funding

The authors acknowledge funding support from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health ( R01EB020640 ) and the Connecticut Regenerative Medicine Research Fund ( 15-RMBUCHC-08 ). Ohan S. Manoukian is the recipient of the National Science Foundation (NSF) Graduate Research Fellowship (Grant No. DGE-1747453). The authors acknowledge funding support from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (R01EB020640) and the Connecticut Regenerative Medicine Research Fund (15-RMBUCHC-08). Ohan S. Manoukian is the recipient of the National Science Foundation (NSF) Graduate Research Fellowship (Grant No. DGE-1747453).

Funders	Funder number
Connecticut Regenerative Medicine Research Fund	15-RMBUCHC-08
National Science Foundation	DGE-1747453
National Institute of Biomedical Imaging and Bioengineering	R01EB020640

Keywords

Biomaterials
Drug delivery
Nerve guidance conduits
Neural tissue engineering
Peripheral nerve injury

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10.1016/j.jconrel.2019.11.021

Cite this

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abstract = "Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.",

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AU - Domb, Abraham J.

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AB - Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.

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Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration

Abstract

Bibliographical note

Funding

Keywords

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