Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Anna Devor; Sava Sakadžić; Mohammad A. Yaseen; Emmanuel Roussakis; Peifang Tian; Hamutal Slovin; Ivo Vanzetta; Ivan Teng; Payam A. Saisan; Louise E. Sinks; Anders M. Dale; Sergei A. Vinogradov; David A. Boas

doi:10.1007/978-1-62703-785-3_14

Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Anna Devor, Sava Sakadžić, Mohammad A. Yaseen, Emmanuel Roussakis, Peifang Tian, Hamutal Slovin, Ivo Vanzetta, Ivan Teng, Payam A. Saisan, Louise E. Sinks, Anders M. Dale, Sergei A. Vinogradov, David A. Boas

The Leslie and Susan Gonda Multidisciplinary Brain Research Center

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

11 Scopus citations

Abstract

Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.

Original language	English
Title of host publication	Optical Imaging of Neocortical Dynamics
Publisher	Humana Press Inc.
Pages	225-253
Number of pages	29
ISBN (Print)	9781627037846
DOIs	https://doi.org/10.1007/978-1-62703-785-3_14
State	Published - 2014

Publication series

Name	Neuromethods
Volume	85
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Funding

Funders	Funder number
American Heart Association	11SDG7600037
National Institute of Biomedical Imaging and Bioengineering Bioengineering	EB00790, EB2066
National Institute of Neurological Disorders and Stroke	NS051188, NS055104, NS057476, NS057198
National Institutes of Health	SIG S10-RR022428

Keywords

CCD
Energy metabolism
Hemoglobin
In vivo imaging
Intrinsic optical signals
Phosphorescence quenching
Two-photon microscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-62703-785-3_14

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Devor, A., Sakadžić, S., Yaseen, M. A., Roussakis, E., Tian, P., Slovin, H., Vanzetta, I., Teng, I., Saisan, P. A., Sinks, L. E., Dale, A. M., Vinogradov, S. A., & Boas, D. A. (2014). Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes. In Optical Imaging of Neocortical Dynamics (pp. 225-253). (Neuromethods; Vol. 85). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-785-3_14

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abstract = "Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.",

keywords = "CCD, Energy metabolism, Hemoglobin, In vivo imaging, Intrinsic optical signals, Phosphorescence quenching, Two-photon microscopy",

author = "Anna Devor and Sava Sakad{\v z}i{\'c} and Yaseen, {Mohammad A.} and Emmanuel Roussakis and Peifang Tian and Hamutal Slovin and Ivo Vanzetta and Ivan Teng and Saisan, {Payam A.} and Sinks, {Louise E.} and Dale, {Anders M.} and Vinogradov, {Sergei A.} and Boas, {David A.}",

year = "2014",

doi = "10.1007/978-1-62703-785-3_14",

language = "אנגלית",

isbn = "9781627037846",

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publisher = "Humana Press Inc.",

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booktitle = "Optical Imaging of Neocortical Dynamics",

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Devor, A, Sakadžić, S, Yaseen, MA, Roussakis, E, Tian, P, Slovin, H, Vanzetta, I, Teng, I, Saisan, PA, Sinks, LE, Dale, AM, Vinogradov, SA & Boas, DA 2014, Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes. in Optical Imaging of Neocortical Dynamics. Neuromethods, vol. 85, Humana Press Inc., pp. 225-253. https://doi.org/10.1007/978-1-62703-785-3_14

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AU - Devor, Anna

AU - Sakadžić, Sava

AU - Yaseen, Mohammad A.

AU - Roussakis, Emmanuel

AU - Tian, Peifang

AU - Slovin, Hamutal

AU - Vanzetta, Ivo

AU - Teng, Ivan

AU - Saisan, Payam A.

AU - Sinks, Louise E.

AU - Dale, Anders M.

AU - Vinogradov, Sergei A.

AU - Boas, David A.

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AB - Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.

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KW - Energy metabolism

KW - Hemoglobin

KW - In vivo imaging

KW - Intrinsic optical signals

KW - Phosphorescence quenching

KW - Two-photon microscopy

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Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Abstract

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Keywords

UN SDGs

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