From Nano to Micro: Using nanotechnology to combat microorganisms and their multidrug resistance

Michal Natan, Ehud Banin

Research output: Contribution to journalReview articlepeer-review

192 Scopus citations


The spread of antibiotic resistance and increasing prevalence of biofilm-associated infections is driving demand for new means to treat bacterial infection. Nanotechnology provides an innovative platform for addressing this challenge, with potential to manage even infections involving multidrug-resistant (MDR) bacteria. The current review summarizes recent progress over the last 2 years in the field of antibacterial nanodrugs, and describes their unique properties, mode of action and activity against MDR bacteria and biofilms. Biocompatibility and commercialization are also discussed. As opposed to the more common division of nanoparticles (NPs) into organic- and inorganic-based materials, this review classifies NPs into two functional categories. The first includes NPs exhibiting intrinsic antibacterial properties and the second is devoted to NPs serving as a cargo for delivering antibacterial agents. Antibacterial nanomaterials used to decorate medical devices and implants are reviewed here as well.

Original languageEnglish
Pages (from-to)302-322
Number of pages21
JournalFEMS Microbiology Reviews
Issue number3
StatePublished - 1 May 2017

Bibliographical note

Publisher Copyright:
© FEMS 2017. All rights reserved.


  • Bacteria
  • Biofilm
  • Medical device
  • Multidrug resistant
  • Nanocarrier
  • Nanoparticles
  • Nanotechnology


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