The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well-defined nanostructures with controlled size and dimensions. Short peptides in particular have received much attention due to their inherent biocompatibility, lower synthetic cost, and ease of tunability. In addition to the diverse self-assembling properties of short peptides comprising coded amino acids and their emerging applications in nanotechnology, there is now growing interest in the properties of peptides composed of non-canonical amino acids. Such non-natural oligomers have been shown in recent years to form well-defined secondary structures similar to natural proteins, with the ability to self-assemble to generate a wide variety of nanostructures with excellent biostability. This review describes recent events in the development of supramolecular assemblies of peptides composed completely of non-coded amino acids and their hybrid analogues. Special attention is paid to understanding the supramolecular assemblies at the atomic level and to considering their potential applications in nanotechnology.
|State||Published - Aug 2021|
Bibliographical noteFunding Information:
This work was supported by the Israel Science Foundation (Grant No. 1732/17) (L.A.‐A.). R.M is thankful to Tel Aviv University and Planning and Budgeting Committee (PBC) for the financial support. The authors thank the members of the Adler‐Abramovich group for helpful discussions.
© 2021 Wiley-VCH GmbH
- hybrid peptides
- non-natural amino acids
- supramolecular assembly