From Folding to Assembly: Functional Supramolecular Architectures of Peptides Comprised of Non-Canonical Amino Acids

Rajkumar Misra, Safra Rudnick-Glick, Lihi Adler-Abramovich

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well-defined nanostructures with controlled size and dimensions. Short peptides in particular have received much attention due to their inherent biocompatibility, lower synthetic cost, and ease of tunability. In addition to the diverse self-assembling properties of short peptides comprising coded amino acids and their emerging applications in nanotechnology, there is now growing interest in the properties of peptides composed of non-canonical amino acids. Such non-natural oligomers have been shown in recent years to form well-defined secondary structures similar to natural proteins, with the ability to self-assemble to generate a wide variety of nanostructures with excellent biostability. This review describes recent events in the development of supramolecular assemblies of peptides composed completely of non-coded amino acids and their hybrid analogues. Special attention is paid to understanding the supramolecular assemblies at the atomic level and to considering their potential applications in nanotechnology.

Original languageEnglish
Article number2100090
JournalMacromolecular Bioscience
Issue number8
StatePublished - Aug 2021
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Israel Science Foundation (Grant No. 1732/17) (L.A.‐A.). R.M is thankful to Tel Aviv University and Planning and Budgeting Committee (PBC) for the financial support. The authors thank the members of the Adler‐Abramovich group for helpful discussions.

Publisher Copyright:
© 2021 Wiley-VCH GmbH


  • crystallography
  • foldamers
  • hybrid peptides
  • non-natural amino acids
  • supramolecular assembly


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