Friction and wear of copper rubbed with lubrication in wide range of loads and sliding velocities were studied. The results of friction and wear experiments are presented as the Stribeck curve where the boundary lubrication (BL), mixed (ML) and elasto-hydrodynamic lubrication (El-IL) regions are considered. The structural state of subsurface layers in different lubricant regions is studied by X-ray photoelectron spectroscopy, optical, transmission and scanning microscopy analysis. Dislocation density of dislocations in El-IL and BL lubricant regimes was determined. Nanohardness at thin surface layers rubbed under different lubricant regimes is compared. The dominant friction and wear mechanisms in different lubrications regions are discussed.