TY - JOUR
T1 - Follicle-stimulating hormone treatment for men with idiopathic oligoteratoasthenozoospermia before in vitro fertilization
T2 - The impact on sperm microstructure and fertilization potential
AU - Ben-Rafael, Zion
AU - Farhi, Jacob
AU - Feldberg, Dov
AU - Bartoov, Benjamin
AU - Kovo, Michal
AU - Eltes, Fina
AU - Ashkenazi, Jacob
N1 - Funding Information:
Supported by a grant from Ares Serono, Geneva, Switzerland.
PY - 2000/1
Y1 - 2000/1
N2 - Objective: To assess the effect of FSH on sperm fertilization potential and sperm intracellular structure in men with oligoteratoasthenozoospermia and a proven low fertilization rate in IVF. Design: Prospective, randomized, partial crossover study. Setting: IVF Unit, Golda Campus, Rabin Medical Center, Petah Tikva, Israel. Patient(s): Forty normogonadotropic, normogonadal men with oligoteratoasthenozoospermia and at least one previous IVF attempt in which fertilization failed or the fertilization rate was <30%. Intervention(s): The men were randomly assigned to treatment with daily injections of 75 IU of FSH or 150 IU of FSH for at least 60 days before IVF treatment. A control group of men underwent an IVF cycle without treatment and then were randomly assigned to join group 1A or 1B for an additional IVF cycle with treatment. Main Outcome Measure(s): LH, FSH, and testosterone levels during FSH treatment, evaluation of ultramorphologic changes in sperm by electron microscopy, and comparison of fertilization rates in the control and study groups. Result(s): After treatment with 75 IU or 150 IU of FSH, the mean fertilization rates were 19.7% and 20.5%, respectively, compared with a 5.8% fertilization rate in the study control cycles. Conclusion(s): Prolonged treatment with FSH results in a significant increase in fertilization rates. This effect may be related to improvements in subcellular components of the sperm.
AB - Objective: To assess the effect of FSH on sperm fertilization potential and sperm intracellular structure in men with oligoteratoasthenozoospermia and a proven low fertilization rate in IVF. Design: Prospective, randomized, partial crossover study. Setting: IVF Unit, Golda Campus, Rabin Medical Center, Petah Tikva, Israel. Patient(s): Forty normogonadotropic, normogonadal men with oligoteratoasthenozoospermia and at least one previous IVF attempt in which fertilization failed or the fertilization rate was <30%. Intervention(s): The men were randomly assigned to treatment with daily injections of 75 IU of FSH or 150 IU of FSH for at least 60 days before IVF treatment. A control group of men underwent an IVF cycle without treatment and then were randomly assigned to join group 1A or 1B for an additional IVF cycle with treatment. Main Outcome Measure(s): LH, FSH, and testosterone levels during FSH treatment, evaluation of ultramorphologic changes in sperm by electron microscopy, and comparison of fertilization rates in the control and study groups. Result(s): After treatment with 75 IU or 150 IU of FSH, the mean fertilization rates were 19.7% and 20.5%, respectively, compared with a 5.8% fertilization rate in the study control cycles. Conclusion(s): Prolonged treatment with FSH results in a significant increase in fertilization rates. This effect may be related to improvements in subcellular components of the sperm.
KW - Electron microscopy
KW - FSH
KW - IVF
KW - OTA
KW - Sperm intracellular microstructure
UR - http://www.scopus.com/inward/record.url?scp=0033976619&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(99)00461-6
DO - 10.1016/S0015-0282(99)00461-6
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 10632407
AN - SCOPUS:0033976619
SN - 0015-0282
VL - 73
SP - 24
EP - 30
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -