Folding on the assembly line

Elisha Haas

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Deciphering the mechanism of folding of newly synthesized proteins in the cell is a major challenge because of the large size and multiplicity of molecular components involved and the asynchrony of biosynthesis. Fluorescently labeled ribosome-bound nascent chains of a defined length were prepared and subjected to dynamic fluorescence depolarization spectroscopy measurements. Nanosecond anisotropy decay correlation times of proteins' nascent chains at different stages of polypeptide elongation were determined for the first time. Striking dependence of the chain dynamics on the stages of elongation was observed and revealed chain length dependence of folding on the ribosome.

Original languageEnglish
Pages (from-to)527-529
Number of pages3
JournalACS Chemical Biology
Issue number9
StatePublished - 19 Sep 2008


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