Fluorescent Mantle Carbon Coated Core-Shell SPIONs for Neuroengineering Applications

Ashish Tiwari, Raj Kumar, Orit Shefi, Jaspreet Kaur Randhawa

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for a variety of biomedical applications, from multimodal imaging to the mechanical activity of cells and tissues. Herein, we present fluorescently mantled carbon coated core-shell superparamagnetic iron oxide nanoparticles (FC-SPIONs) as an excellent material to promote the neuronal differentiation and neuronal network outgrowth in neural tissue engineering applications. Morphological, structural, and functional group characterizations were systematically investigated. FC-SPIONs showed superior magnetic and inherent fluorescence characteristic properties. Furthermore, FC-SPIONs interactions against neuronal PC12 cells showed promising results and deliberate their potential for significant applications in neuroengineering. Interestingly, FC-SPIONs were assessed as biocompatible and promoted the neuronal PC12 cell differentiation process. Accompanied by these results, network outgrowth and branching patterns of neuronal processes can be regulated using FC-SPIONs. Importantly, FC-SPIONs are promising due to their biocompatibility and selective affinity toward neuronal cells, paving the way for neuronal differentiation and outgrowth and neuronal therapeutics in neuroengineering applications.

Original languageEnglish
Pages (from-to)4665-4673
Number of pages9
JournalACS Applied Bio Materials
Volume3
Issue number7
DOIs
StatePublished - 20 Jul 2020

Bibliographical note

Publisher Copyright:
Copyright © 2020 American Chemical Society.

Keywords

  • core-shell nanoparticles
  • magneto-fluorescent nanoparticles
  • neural cell differentiation and outgrowth
  • neural tissue engineering
  • superparamagnetic iron oxide nanoparticles

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