Fluorescent-functionalized graphene oxide for selective labeling of tumor cells

Sudipta Senapati, Dinesh K. Patel, Biswajit Ray, Pralay Maiti

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Fluorescence probe has attracted significant attention for biomedical imaging in recent years due to their high resolution at the cellular level. Organic-based fluorescent probes with high quantum yield are widely applied in bioimaging, but most of them suffer from a serious obstacle called aggregation-caused quenching in cellular systems. New fluorophore has been designed through functionalization of graphene oxide which emphatically exhibits aggregation-induced emission along with pH-responsive nanoprobe. Significantly higher emission of this material in slightly acidic media helps to detect tumor cell by creating a sharp contrast with the image of normal cells. The reason for pH-induced enhanced emission phenomenon is revealed through aggregation of sulfonated species in acidic media. Furthermore, the biocompatible nature of the newly developed material is found to be suitable for its application in biomedical imaging for cancer detection with better accuracy at lower cost.

Original languageEnglish
Pages (from-to)1917-1924
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Issue number9
StatePublished - Sep 2019
Externally publishedYes

Bibliographical note

Funding Information:
The authors gratefully acknowledge the financial support from Institute Research Project (Individual Faculty sanction No. IIT(BHU)/R&D/IRP/2015-16/2817) and SERB Project No. EMR/2015/001409. The authors are also thankful to Central Instrument Facility (CIF), IIT (BHU), Varanasi, for TEM and AFM measurements.

Funding Information:
Additional Supporting Information may be found in the online version of this article. Correspondence to: P. Maiti; e-mail: pmaiti.mst@itbhu.ac.in Contract grant sponsor: SERB; contract grant number: EMR/2015/001409 Contract grant sponsor: Institute Research Project; contract grant number: IIT(BHU)/R&D/IRP/2015-16/2817

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.


  • aggregation-induced emission
  • functionalized graphene oxide
  • targeted tumor imaging


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