Fluorescent Copper Probe Inhibiting Aβ1-16-Copper(II)-Catalyzed Intracellular Reactive Oxygen Species Production

Gulshan R. Walke, Dnyanesh S. Ranade, Shefali N. Ramteke, Srikanth Rapole, Cristina Satriano, Enrico Rizzarelli, Gaetano A. Tomaselli, Giuseppe Trusso Sfrazzetto, Prasad P. Kulkarni

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A variety of fluorescent probes are proposed to monitor the intracellular copper content. So far, none of the probes have been evaluated for their potential to inhibit copper-associated intracellular oxidative stress. Herein, we studied the ability of a fluorescent copper probe, OBEP-CS1, to inhibit intracellular oxidative stress associated with an amyloid β (Aβ) peptide-copper complex. The data showed that OBEP-CS1 completely inhibits the copper-catalyzed oxidation as well as decarboxylation/deamination of Aβ1-16. Moreover, the cell imaging experiments confirmed that OBEP-CS1 can inhibit Aβ-CuII-catalyzed reactive oxygen species production in SH-SY5Y cells. We also demonstrated that Aβ1-16 peptide can bind intracellular copper and thereby exert oxidative stress.

Original languageEnglish
Pages (from-to)3729-3732
Number of pages4
JournalInorganic Chemistry
Issue number7
StatePublished - 3 Apr 2017
Externally publishedYes

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© 2017 American Chemical Society.


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