Abstract
A variety of fluorescent probes are proposed to monitor the intracellular copper content. So far, none of the probes have been evaluated for their potential to inhibit copper-associated intracellular oxidative stress. Herein, we studied the ability of a fluorescent copper probe, OBEP-CS1, to inhibit intracellular oxidative stress associated with an amyloid β (Aβ) peptide-copper complex. The data showed that OBEP-CS1 completely inhibits the copper-catalyzed oxidation as well as decarboxylation/deamination of Aβ1-16. Moreover, the cell imaging experiments confirmed that OBEP-CS1 can inhibit Aβ-CuII-catalyzed reactive oxygen species production in SH-SY5Y cells. We also demonstrated that Aβ1-16 peptide can bind intracellular copper and thereby exert oxidative stress.
Original language | English |
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Pages (from-to) | 3729-3732 |
Number of pages | 4 |
Journal | Inorganic Chemistry |
Volume | 56 |
Issue number | 7 |
DOIs | |
State | Published - 3 Apr 2017 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2017 American Chemical Society.