Fluorescence for biological logic gates

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Biological logic gates are smart probes able to respond to biological conditions in behaviors similar to computer logic gates, and they pose a promising challenge for modern medicine. Researchers are creating many kinds of smart nanostructures that can respond to various biological parameters such as pH, ion presence, and enzyme activity. Each of these conditions alone might be interesting in a biological sense, but their interactions are what define specific disease conditions. Researchers over the past few decades have developed a plethora of stimuli-responsive nanodevices, from activatable fluorescent probes to DNA origami nanomachines, many explicitly defining logic operations. Whereas many smart configurations have been explored, in this review we focus on logic operations actuated through fluorescent signals. We discuss the applicability of fluorescence as a means of logic gate implementation, and consider the use of both fluorescence intensity as well as fluorescence lifetime.

Original languageEnglish
Article numbere202000158
JournalJournal of Biophotonics
Volume13
Issue number9
DOIs
StatePublished - 1 Sep 2020

Bibliographical note

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

Israel Science Foundation, Grant/Award Number: 1195/18; Israeli Ministry of Science, Technology, and Space, Grant/Award Number: 3‐13334 Funding information This work was supported by the Israeli Ministry of Science, Technology, and Space Grant 3‐13334 and by the Israel Science Foundation, ISF (grant No. 1195/18).

FundersFunder number
Israeli ministry of science, technology3‐13334
Israel Science Foundation1195/18
Ministry of science and technology, Israel

    Keywords

    • FLIM
    • biological logic gates
    • fluorescence
    • molecular logic gates
    • reactive probes
    • smart probes

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