TY - JOUR
T1 - Fluid shear stress and the vascular endothelium
T2 - For better and for worse
AU - Resnick, Nitzan
AU - Yahav, Hava
AU - Shay-Salit, Ayelet
AU - Shushy, Moran
AU - Schubert, Shay
AU - Zilberman, Limor Chen Michal
AU - Wofovitz, Efrat
N1 - Funding Information:
This work was supported in part by the Israel-United States Binational Scientific Fund (BSF), #1998114 and by the Israeli Ministry of Science (Tashtiot) Fund #1000053.
PY - 2003/4
Y1 - 2003/4
N2 - As blood flows, the vascular wall is constantly subjected to physical forces, which regulate important physiological blood vessel responses, as well as being implicated in the development of arterial wall pathologies. Changes in blood flow, thus generating altered hemodynamic forces are responsible for acute vessel tone regulation, the development of blood vessel structure during embryogenesis and early growth, as well as chronic remodeling and generation of adult blood vessels. The complex interaction of biomechanical forces, and more specifically shear stress, derived by the flow of blood and the vascular endothelium raise many yet to be answered questions:(1) How are mechanical forces transduced by endothelial cells into a biological response, and is there a "shear stress receptor"?(2) Are "mechanical receptors" and the final signaling pathways they evoke similar to other stimulus-response transduction systems?(3) How do vascular endothelial cells differ in their response to physiological or pathological shear stresses?(4) Can shear stress receptors or shear stress responsive genes serve as novel targets for the design of diagnostic and therapeutic modalities for cardiovascular pathologies? The current review attempts to bring together recent findings on the in vivo and in vitro responses of the vascular endothelium to shear stress and to address some of the questions raised above.
AB - As blood flows, the vascular wall is constantly subjected to physical forces, which regulate important physiological blood vessel responses, as well as being implicated in the development of arterial wall pathologies. Changes in blood flow, thus generating altered hemodynamic forces are responsible for acute vessel tone regulation, the development of blood vessel structure during embryogenesis and early growth, as well as chronic remodeling and generation of adult blood vessels. The complex interaction of biomechanical forces, and more specifically shear stress, derived by the flow of blood and the vascular endothelium raise many yet to be answered questions:(1) How are mechanical forces transduced by endothelial cells into a biological response, and is there a "shear stress receptor"?(2) Are "mechanical receptors" and the final signaling pathways they evoke similar to other stimulus-response transduction systems?(3) How do vascular endothelial cells differ in their response to physiological or pathological shear stresses?(4) Can shear stress receptors or shear stress responsive genes serve as novel targets for the design of diagnostic and therapeutic modalities for cardiovascular pathologies? The current review attempts to bring together recent findings on the in vivo and in vitro responses of the vascular endothelium to shear stress and to address some of the questions raised above.
UR - http://www.scopus.com/inward/record.url?scp=0038364117&partnerID=8YFLogxK
U2 - 10.1016/S0079-6107(02)00052-4
DO - 10.1016/S0079-6107(02)00052-4
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 12732261
AN - SCOPUS:0038364117
SN - 0079-6107
VL - 81
SP - 177
EP - 199
JO - Progress in Biophysics and Molecular Biology
JF - Progress in Biophysics and Molecular Biology
IS - 3
ER -