Fluctuation and synchronization of gait intervals and gait force profiles distinguish stages of Parkinson's disease

Ronny Bartsch; Meir Plotnik; Jan W. Kantelhardt; Shlomo Havlin; Nir Giladi; Jeffrey M. Hausdorff

doi:10.1016/j.physa.2007.04.120

Fluctuation and synchronization of gait intervals and gait force profiles distinguish stages of Parkinson's disease

Ronny Bartsch
, Meir Plotnik
, Jan W. Kantelhardt
, Shlomo Havlin
, Nir Giladi
, Jeffrey M. Hausdorff

Department of Physics - at Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

We study the effects of Parkinson's disease (PD) on the long-term fluctuation and phase synchronization properties of gait timing (series of interstride intervals) as well as gait force profiles (series characterizing the morphological changes between the steps). We find that the fluctuations in the gait timing are significantly larger for PD patients and early PD patients, who were not treated yet with medication, compared to age-matched healthy controls. Simultaneously, the long-term correlations and the phase synchronization of right and left leg are significantly reduced in both types of PD patients. Surprisingly, long-term correlations of the gait force profiles are relatively weak for treated PD patients and healthy controls, while they are significantly larger for early PD patients. The results support the idea that timing and morphology of recordings obtained from a complex system can contain complementary information.

Original language	English
Pages (from-to)	455-465
Number of pages	11
Journal	Physica A: Statistical Mechanics and its Applications
Volume	383
Issue number	2
DOIs	https://doi.org/10.1016/j.physa.2007.04.120
State	Published - 15 Sep 2007

Bibliographical note

Funding Information:
We thank Shay Moshel, Avi Gozolchiani and Leor Gruendlinger for helpful discussions as well as the subjects for their participation, time and effort. This work was supported in part by the Minerva Foundation, by NIH Grants AG-14100, RR-13622, HD-39838 and AG-08812, by the US-Israel Binational Science Foundation, by the Parkinson's Disease Foundation (PDF), New York, by the National Parkinson Foundation (NPF), Miami USA, by the EU project DAPHNet (Grant 018474-2), and by the Deutsche Forschungsgemeinschaft (Grant KA 1676/3).

Funding

We thank Shay Moshel, Avi Gozolchiani and Leor Gruendlinger for helpful discussions as well as the subjects for their participation, time and effort. This work was supported in part by the Minerva Foundation, by NIH Grants AG-14100, RR-13622, HD-39838 and AG-08812, by the US-Israel Binational Science Foundation, by the Parkinson's Disease Foundation (PDF), New York, by the National Parkinson Foundation (NPF), Miami USA, by the EU project DAPHNet (Grant 018474-2), and by the Deutsche Forschungsgemeinschaft (Grant KA 1676/3).

Funders	Funder number
Miami
National Institutes of Health	RR-13622, AG-08812, HD-39838, AG-14100
National Parkinson Foundation
Parkinson's Disease Foundation
European Commission	018474-2
Minerva Foundation
Deutsche Forschungsgemeinschaft	KA 1676/3
United States-Israel Binational Science Foundation

Keywords

Detrended fluctuation analysis
Gait
Parkinson's disease
Phase synchronization

Access to Document

10.1016/j.physa.2007.04.120

Cite this

@article{e5bf3bb000ff4220bdde92b858ca3379,

title = "Fluctuation and synchronization of gait intervals and gait force profiles distinguish stages of Parkinson's disease",

abstract = "We study the effects of Parkinson's disease (PD) on the long-term fluctuation and phase synchronization properties of gait timing (series of interstride intervals) as well as gait force profiles (series characterizing the morphological changes between the steps). We find that the fluctuations in the gait timing are significantly larger for PD patients and early PD patients, who were not treated yet with medication, compared to age-matched healthy controls. Simultaneously, the long-term correlations and the phase synchronization of right and left leg are significantly reduced in both types of PD patients. Surprisingly, long-term correlations of the gait force profiles are relatively weak for treated PD patients and healthy controls, while they are significantly larger for early PD patients. The results support the idea that timing and morphology of recordings obtained from a complex system can contain complementary information.",

keywords = "Detrended fluctuation analysis, Gait, Parkinson's disease, Phase synchronization",

author = "Ronny Bartsch and Meir Plotnik and Kantelhardt, \{Jan W.\} and Shlomo Havlin and Nir Giladi and Hausdorff, \{Jeffrey M.\}",

note = "Funding Information: We thank Shay Moshel, Avi Gozolchiani and Leor Gruendlinger for helpful discussions as well as the subjects for their participation, time and effort. This work was supported in part by the Minerva Foundation, by NIH Grants AG-14100, RR-13622, HD-39838 and AG-08812, by the US-Israel Binational Science Foundation, by the Parkinson's Disease Foundation (PDF), New York, by the National Parkinson Foundation (NPF), Miami USA, by the EU project DAPHNet (Grant 018474-2), and by the Deutsche Forschungsgemeinschaft (Grant KA 1676/3).",

year = "2007",

month = sep,

day = "15",

doi = "10.1016/j.physa.2007.04.120",

language = "אנגלית",

volume = "383",

pages = "455--465",

journal = "Physica A: Statistical Mechanics and its Applications",

issn = "0378-4371",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Fluctuation and synchronization of gait intervals and gait force profiles distinguish stages of Parkinson's disease

AU - Bartsch, Ronny

AU - Plotnik, Meir

AU - Kantelhardt, Jan W.

AU - Havlin, Shlomo

AU - Giladi, Nir

AU - Hausdorff, Jeffrey M.

N1 - Funding Information: We thank Shay Moshel, Avi Gozolchiani and Leor Gruendlinger for helpful discussions as well as the subjects for their participation, time and effort. This work was supported in part by the Minerva Foundation, by NIH Grants AG-14100, RR-13622, HD-39838 and AG-08812, by the US-Israel Binational Science Foundation, by the Parkinson's Disease Foundation (PDF), New York, by the National Parkinson Foundation (NPF), Miami USA, by the EU project DAPHNet (Grant 018474-2), and by the Deutsche Forschungsgemeinschaft (Grant KA 1676/3).

PY - 2007/9/15

Y1 - 2007/9/15

N2 - We study the effects of Parkinson's disease (PD) on the long-term fluctuation and phase synchronization properties of gait timing (series of interstride intervals) as well as gait force profiles (series characterizing the morphological changes between the steps). We find that the fluctuations in the gait timing are significantly larger for PD patients and early PD patients, who were not treated yet with medication, compared to age-matched healthy controls. Simultaneously, the long-term correlations and the phase synchronization of right and left leg are significantly reduced in both types of PD patients. Surprisingly, long-term correlations of the gait force profiles are relatively weak for treated PD patients and healthy controls, while they are significantly larger for early PD patients. The results support the idea that timing and morphology of recordings obtained from a complex system can contain complementary information.

AB - We study the effects of Parkinson's disease (PD) on the long-term fluctuation and phase synchronization properties of gait timing (series of interstride intervals) as well as gait force profiles (series characterizing the morphological changes between the steps). We find that the fluctuations in the gait timing are significantly larger for PD patients and early PD patients, who were not treated yet with medication, compared to age-matched healthy controls. Simultaneously, the long-term correlations and the phase synchronization of right and left leg are significantly reduced in both types of PD patients. Surprisingly, long-term correlations of the gait force profiles are relatively weak for treated PD patients and healthy controls, while they are significantly larger for early PD patients. The results support the idea that timing and morphology of recordings obtained from a complex system can contain complementary information.

KW - Detrended fluctuation analysis

KW - Gait

KW - Parkinson's disease

KW - Phase synchronization

UR - https://www.scopus.com/pages/publications/34447095893

U2 - 10.1016/j.physa.2007.04.120

DO - 10.1016/j.physa.2007.04.120

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

SN - 0378-4371

VL - 383

SP - 455

EP - 465

JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

IS - 2

ER -

Fluctuation and synchronization of gait intervals and gait force profiles distinguish stages of Parkinson's disease

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this