Flavobacteriaceae bacteremia in children: A multicenter study

Shiri Cooper, Itzhak Levy, Haim Ben-Zvi, Liat Ashkenazi-Hoffnung, Shalom Ben-Shimol, Yael Shachor-Meyouhas, Galia Grisaru-Soen, Or Kriger, Dafna Yahav, Oded Scheuerman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: The Flavobacteriaceae family includes rare pathogens in children; Chryseobacterium indologenes and Elizabethkingia meningosepticum are the most common pathogenic species, with a wide range of clinical presentations and high mortality rate. Although rare, diagnosis is important due to inherent resistance to multiple antibiotics, especially those typically prescribed for empiric treatment of aerobic Gram-negative bacterial infections. Methods: A multicenter retrospective study conducted in 5 Israeli hospitals, describing Flavobacteriaceae bacteremia confirmed by positive blood culture from 1998 to 2018. Results: Thirteen cases were included; 9 isolates were C. indologenes. Bacteremia was nosocomial or healthcare-associated in all cases. Bacteremia was associated with young age (median, 1 year, range 24 days-17 years), with only 2 (15.4%) cases in neonates, Central line-associated bloodstream infection as a source (5/13, 38%) and malignancy (7/13, 54.8%). Thirty-day all-cause mortality was 23% (3/13). Ninety-one percent of isolates were susceptible to trimethoprim-sulfamethoxazole, 82% to piperacillin-tazobactam and 92% to ciprofloxacin. Conclusions: C. indologenes and E. meningosepticum are rare, nosocomial-or healthcare-associated pediatric bacteremia pathogens. Bacteremia was associated with young age, but in contrast to the literature, the majority of our cases were older than the neonatal age period. In addition, they were associated with central line-associated bloodstream infection and malignancy. The most adequate antibiotics according to resistance patterns were ciprofloxacin, trimethoprim-sulfamethoxazole and piperacillin-tazobactam.

Original languageEnglish
Pages (from-to)1096-1099
Number of pages4
JournalPediatric Infectious Disease Journal
Issue number11
StatePublished - 1 Nov 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.


  • Chryseobacterium indologenes
  • Chryseobacterium meningosepticum
  • Elizabethkingae meningosepticum
  • Pediatrics


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