Fiber optic based multiprobe system for intraoperative monitoring of brain functions

A. Mayevsky, E. S. Flamm, W. Pennie, B. Chance

Research output: Contribution to journalConference articlepeer-review

36 Scopus citations


In order to monitor various functions of the brain we have developed a new multiprobe (MPA) assembly, based on fiber optic probes and ion selective electrodes, enabling the assessment of relative CBF, mitochondrial redox state (NADH fluorescence) and ion homeostasis in real-time, intraoperatively. The base features of the multiprobe assembly were described previously. For the Laser Doppler flowmetry one input fiber and two output fibers were glued in a triangular shape and connected to the standard commercial plug of the Laser Doppler flowmeter. For the monitoring of NADH redox state 10 excitation and 10 emission fibers were randomly mixed between and around the fibers used for the Laser Doppler flowmetry. This configuration of the fibers enabled us to monitor CBF and NADH redox state from about the same tissue volume. The preliminary results obtained suggest that the usage of the MPA in the operating room may have a significant contribution to the neurosurgeon as a routine diagnostic tool. It seems to us that a simplified MPA which will enable to monitor only the relative CBF, NADH redox state as well as extracellular K+ is more appropriate for future usage.

Original languageEnglish
Pages (from-to)303-313
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1991
Externally publishedYes
EventProceedings of Time-Resolved Spectroscopy and Imaging of Tissues - Los Angeles, CA, USA
Duration: 23 Jan 199124 Jan 1991


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