Fiber optic based muitiparametric spectroscopy in vivo: Toward a new quantitative tissue vitality index

Hofit Kutai-Asis, Efrat Barbiro-Michaely, Assaf Deutsch, Avraham Mayevsky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

In our previous publication (Mayevsky et al SPIE 5326: 98-105, 2004) we described a multiparametric fiber optic system enabling the evaluation of 4 physiological parameters as indicators of tissue vitality. Since the correlation between the various parameters may differ in various pathophysiological conditions there is a need for an objective quantitative index that will integrate the relative changes measured in real time by the multiparametric monitoring system into a single number-vitality index. Such an approach to calculate tissue vitality index is critical for the possibility to use such an instrument in clinical environments. In the current presentation we are reporting our preliminary results indicating that calculation of an objective tissue vitality index is feasible. We used an intuitive empirical approach based on the comparison between the calculated index by the computer and the subjective evaluation made by an expert in the field of physiological monitoring. We used the in vivo brain of rats as an animal model in our current studies. The rats were exposed to anoxia, ischemia and cortical spreading depression and the responses were recorded in real time. At the end of the monitoring session the results were analyzed and the tissue vitality index was calculated offline. Mitochondrial NADH, tissue blood flow and oxy-hemoglobin were used to calculate the vitality index of the brain in vivo, where each parameter received a different weight, in each experiment type based on their significance. It was found that the mitochondrial NADH response was the main factor affected the calculated vitality index.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
DOIs
StatePublished - 2006
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI - San Jose, CA, United States
Duration: 21 Jan 200622 Jan 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6083
ISSN (Print)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI
Country/TerritoryUnited States
CitySan Jose, CA
Period21/01/0622/01/06

Keywords

  • CBF
  • HbO
  • Mitochondrial NADH
  • Tissue Vitality Index

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