Fetal eyeball volume: Relationship to gestational age and biparietal diameter

Marwan Odeh, Yulia Feldman, Shimon Degani, Vitali Grinin, Ella Ophir, Jacob Bornstein

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: To measure and determine normal values of the fetal eyeball volume between 14 and 40 weeks of gestation. Methods: The volume of the fetal eyeball was measured with three-dimensional ultrasound between 14 and 40 weeks of gestation using the VOCAL software. Only singleton pregnancies without fetal growth restriction, diabetes mellitus, hypertension or major fetal malformation were included. Results: Over all, 203 women were studied. In 125 both eyeballs were measured while in 78 only one eyeball was measured. The volume of the eyeball correlated strongly with gestational age (right: R = 0.946, P < 0.001, n = 171. left: R = 0.945, P < 0.001, n = 156), and with the biparietal diameter (BPD) (right: R = 0.949, P < 0.001, n = 171. left: R = 0.953, P < 0.001, n = 156). Using regression analysis the best correlation between eyeball volume and the BPD were: square of right eyeball = -0.180 + 0.187 BPD, square of left eyeball= -0.182 + 0.187 BPD. Conclusions: The volume of the eyeball has strong positive correlations with gestational age and BPD. Our data may be helpful in fetuses suspected of having eye anomalies.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalPrenatal Diagnosis
Volume29
Issue number8
DOIs
StatePublished - Aug 2009
Externally publishedYes

Keywords

  • Biparietal diameter
  • Eyeball volume
  • Gestational age
  • Three-dimensional ultrasound

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