Fentanyl Initiated Polymers Prepared by ATRP for Targeted Delivery

Devora Cohen-Karni, Marina Kovaliov, Shaohua Li, Stephen Jaffee, Nestor D. Tomycz, Saadyah Averick

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The targeted delivery of polymers to neurons is a challenging yet important goal for polymer based drug delivery. We prepared a fentanyl based atom transfer radical polymerization (ATRP) initiator to target the Mu opioid receptor (MOR) for neuronal targeting. We incorporated our recently discovered rigid acrylate linking group into the initiator to retain a high degree of binding to the MOR and grafted random or block copolymers of poly(oligo(ethylene oxide) methacrylate)-block-(glycidyl methacrylate). Trifluoroethanol promoted amine ring opening of the glycidyl methacrylate was used for post-polymerization modification of the fentanyl initiated polymers to attach a near-infrared fluorescent dye (ADS790WS) or to build a targeted siRNA delivery system via modification with secondary amines. We examined the biocompatibility, cellular internalization, and siRNA binding properties of our polymer library in a green fluorescent protein expressing SY SH5Y neuroblastoma cell-line.

Original languageEnglish
Pages (from-to)1251-1259
Number of pages9
JournalBioconjugate Chemistry
Issue number4
StatePublished - 19 Apr 2017
Externally publishedYes

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Publisher Copyright:
© 2017 American Chemical Society.


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