Abstract
Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.
| Original language | English |
|---|---|
| Article number | e1449584 |
| Journal | Molecular and Cellular Oncology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - 4 Jul 2018 |
Bibliographical note
Publisher Copyright:© 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, Alessandro Genna and Hava Gil-Henn.
Funding
Research in the Gil-Henn laboratory is supported by the Israel Cancer Association and Estee Lauder Companies (grant number 20180089), the Israel Science Foundation (grant number 1462/17), and the Israel Cancer Research Fund (grant number 17-902-AG).
| Funders | Funder number |
|---|---|
| Estee Lauder Companies | 20180089 |
| Israel Cancer Research Fund | 17-902-AG |
| Israel Cancer Association | |
| Israel Science Foundation | 1462/17 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- FAK
- Pyk2
- focal adhesions
- invadopodia
- invasion
- migration
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