FAK family kinases: The Yin and Yang of cancer cell invasiveness

Alessandro Genna, Hava Gil-Henn

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.

Original languageEnglish
Article numbere1449584
JournalMolecular and Cellular Oncology
Volume5
Issue number4
DOIs
StatePublished - 4 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, Alessandro Genna and Hava Gil-Henn.

Keywords

  • FAK
  • Pyk2
  • focal adhesions
  • invadopodia
  • invasion
  • migration

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