FAK family kinases: The Yin and Yang of cancer cell invasiveness

Alessandro Genna; Hava Gil-Henn

doi:10.1080/23723556.2018.1449584

FAK family kinases: The Yin and Yang of cancer cell invasiveness

Alessandro Genna, Hava Gil-Henn

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.

Original language	English
Article number	e1449584
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2018.1449584
State	Published - 4 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, Alessandro Genna and Hava Gil-Henn.

Keywords

FAK
Pyk2
focal adhesions
invadopodia
invasion
migration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2018.1449584

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title = "FAK family kinases: The Yin and Yang of cancer cell invasiveness",

abstract = "Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.",

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author = "Alessandro Genna and Hava Gil-Henn",

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AU - Gil-Henn, Hava

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AB - Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.

KW - FAK

KW - Pyk2

KW - focal adhesions

KW - invadopodia

KW - invasion

KW - migration

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FAK family kinases: The Yin and Yang of cancer cell invasiveness

Abstract

Bibliographical note

Keywords

UN SDGs

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