Factors in oxygen delivery to tissue

Britton Chance, Avraham Mayevsky, Cleon Goodwin, Leena Mela

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


An animal model for evaluating oxygen delivery to tissue is based upon the determination of the intracellular oxygen tension by surface fluorometry of NADH under conditions where the inspired oxygen is reduced through the critical value for the particular organ. This procedure allows the evaluation of the overall efficiency of the pulmonocardiac tissue in delivering oxygen to tissue, and can be useful in new, quantitative measurements of the effect of various factors occurring between the inspired air and the final tissue oxygen tension.

Original languageEnglish
Pages (from-to)276-282
Number of pages7
JournalMicrovascular Research
Issue number3
StatePublished - Nov 1974
Externally publishedYes


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