Factors associated with withdrawal bleeding after administration of oral dydrogesterone or medroxyprogesterone acetate in women with secondary amenorrhea?

S. Battino, M. Ben-Ami, Y. Geslevich, E. Weiner, E. Shalev

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The effectiveness of two treatment regimens in inducing withdrawal bleeding in secondary amenorrhea was compared and correlated with the endometrial thickness and endogenous E2 and progesterone concentrations. A prospective, randomized and double-blind study was designed at the Outpatient Clinic of Reproductive Endocrinology, Central Emek Hospital, Afula, Israel. Seventy-seven premenopausal women with oligomenorrhea or amenorrhea, 48 of whom qualified for the study, underwent a 5-day course of either medroxypro-gesterone acetate (MPA) 5 mg b.i.d. Or dydrogesterone (DG) 10 mg b.i.d. Endogenous pretreatment values of E2 and progesterone and endometrial thickness (by transvaginal ultrasonography) were correlated with the bleeding response. Withdrawal bleeding, changes in lipids and side effects were compared. Withdrawal bleeding occurred in 93% of women taking either MPA or DG. Side effects occurred similarly among the groups. Lipid concentrations were unchanged. Endogenous E2 and progesterone were of limited predictive value for withdrawal bleeding. Endometrial thickness as measured by transvaginal sonography correlated significantly with the bleeding response.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume42
Issue number2
DOIs
StatePublished - 1 Jan 1996
Externally publishedYes

Keywords

  • Progestational treatment
  • Secondary amenorrhea

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