Extracorporeal removal of mercury by hemoperfusion through agarose—polymercaptal microsphere beads

Shlomo Margel, Leon Marcus, Aharon Mashiah, Hillel Savin, Michael Dalit

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Uniform agarose—polymercaptal microsphere beads (APMMB) of 1.0‐mm diameter were prepared by encapsulating thousands of polymercaptal microspheres of 0.8‐μm average diameter within an agarose matrix. Those beads show a high avidity and affinity for mercury and readily remove mercury compounds bound to serum proteins. In vivo detoxification trials in dosed rabbits and dogs showed the effectiveness of the APMMB for removal of mercury compounds by hemoperfusion. The rate for mercury removal is enhanced by addition of cysteine. The biocompatibility of the APMMB, measured by the depletion of the formed elements and various soluble components of the blood, is also demonstrated.

Original languageEnglish
Pages (from-to)617-629
Number of pages13
JournalJournal of Biomedical Materials Research
Volume18
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

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