Extracellular RNAs: Development as biomarkers of human disease

Joseph F. Quinn, Tushar Patel, David Wong, Saumya Das, Jane E. Freedman, Louise C. Laurent, Bob S. Carter, Fred Hochberg, Kendall Van Keuren-Jensen, Matt Huentelman, Robert Spetzler, M. Yashar S. Kalani, Jorge Arango, P. David Adelson, Howard L. Weiner, Roopali Gandhi, Beatrice Goilav, Chaim Putterman, Julie A. Saugstad

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage,multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.

Original languageEnglish
Article number27495
JournalJournal of Extracellular Vesicles
Issue number1
StatePublished - 2015
Externally publishedYes

Bibliographical note

Funding Information:
We thank the NIH Common Fund for support these studies, via the NCATS UH2/UH3 Grants TR000931; TR000890; TR000921; TR000891; TR000906; TR000884; TR000903; TR000901; TR000923; TR000933. Also supported by NIA-AG08017. We also thank Dr. Thomas Tuschl and Dr. Manikkam Suthanthiran for feedback regarding this review. David Wong is co-founder of RNAmeTRIX Inc., a molecular diagnostic company. He holds equity in RNAmeTRIX, and serves as a company Director and Scientific Advisor. The University of California also holds equity in RNAme-TRIX. Intellectual property that David Wong invented and which was patented by the University of California has been licensed to RNAmeTRIX. All other authors have not received any funding or benefits from industry or elsewhere to conduct this study.

Publisher Copyright:
© 2015 Joseph F. Quinn et al.


  • Biomarkers
  • ERCC
  • ExRNA
  • Extracellular RNA


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