Extracellular RNAs: Development as biomarkers of human disease

Joseph F. Quinn; Tushar Patel; David Wong; Saumya Das; Jane E. Freedman; Louise C. Laurent; Bob S. Carter; Fred Hochberg; Kendall Van Keuren-Jensen; Matt Huentelman; Robert Spetzler; M. Yashar S. Kalani; Jorge Arango; P. David Adelson; Howard L. Weiner; Roopali Gandhi; Beatrice Goilav; Chaim Putterman; Julie A. Saugstad

doi:10.3402/jev.v4.27495

Extracellular RNAs: Development as biomarkers of human disease

Joseph F. Quinn, Tushar Patel, David Wong, Saumya Das, Jane E. Freedman, Louise C. Laurent, Bob S. Carter, Fred Hochberg, Kendall Van Keuren-Jensen, Matt Huentelman, Robert Spetzler, M. Yashar S. Kalani, Jorge Arango, P. David Adelson, Howard L. Weiner, Roopali Gandhi, Beatrice Goilav, Chaim Putterman, Julie A. Saugstad

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage,multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.

Original language	English
Article number	27495
Journal	Journal of Extracellular Vesicles
Volume	4
Issue number	1
DOIs	https://doi.org/10.3402/jev.v4.27495
State	Published - 2015
Externally published	Yes

Bibliographical note

Funding Information:
We thank the NIH Common Fund for support these studies, via the NCATS UH2/UH3 Grants TR000931; TR000890; TR000921; TR000891; TR000906; TR000884; TR000903; TR000901; TR000923; TR000933. Also supported by NIA-AG08017. We also thank Dr. Thomas Tuschl and Dr. Manikkam Suthanthiran for feedback regarding this review. David Wong is co-founder of RNAmeTRIX Inc., a molecular diagnostic company. He holds equity in RNAmeTRIX, and serves as a company Director and Scientific Advisor. The University of California also holds equity in RNAme-TRIX. Intellectual property that David Wong invented and which was patented by the University of California has been licensed to RNAmeTRIX. All other authors have not received any funding or benefits from industry or elsewhere to conduct this study.

Publisher Copyright:
© 2015 Joseph F. Quinn et al.

Keywords

Biomarkers
ERCC
ExRNA
Extracellular RNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3402/jev.v4.27495

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Quinn, J. F., Patel, T., Wong, D., Das, S., Freedman, J. E., Laurent, L. C., Carter, B. S., Hochberg, F., Van Keuren-Jensen, K., Huentelman, M., Spetzler, R., Kalani, M. Y. S., Arango, J., Adelson, P. D., Weiner, H. L., Gandhi, R., Goilav, B., Putterman, C., & Saugstad, J. A. (2015). Extracellular RNAs: Development as biomarkers of human disease. Journal of Extracellular Vesicles, 4(1), Article 27495. https://doi.org/10.3402/jev.v4.27495

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Quinn, JF, Patel, T, Wong, D, Das, S, Freedman, JE, Laurent, LC, Carter, BS, Hochberg, F, Van Keuren-Jensen, K, Huentelman, M, Spetzler, R, Kalani, MYS, Arango, J, Adelson, PD, Weiner, HL, Gandhi, R, Goilav, B, Putterman, C & Saugstad, JA 2015, 'Extracellular RNAs: Development as biomarkers of human disease', Journal of Extracellular Vesicles, vol. 4, no. 1, 27495. https://doi.org/10.3402/jev.v4.27495

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Extracellular RNAs: Development as biomarkers of human disease

Abstract

Bibliographical note

Keywords

UN SDGs

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