TY - JOUR
T1 - Extracellular DAMPs in Plants and Mammals
T2 - Immunity, Tissue Damage and Repair
AU - De Lorenzo, Giulia
AU - Ferrari, Simone
AU - Cervone, Felice
AU - Okun, Eitan
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Innate immune receptors, well known mediators of response to non-self-molecules and inflammation, also act as mediators of immunity triggered by ‘damage-associated molecular patterns’ (DAMPs). Pathogen-associated molecular patterns (PAMPs) cause inflammation in mammals and a rapid immune response in plants, while DAMPs trigger more complex responses, including immunity, tissue maintenance and repair. DAMPs, their receptors and downstream transduction mechanisms are often conserved within a kingdom or, due to convergent evolution, are similar across the kingdoms of life. Herein, we describe the dynamics and functionality of specific extracellular DAMP classes and their receptors in immunity, inflammation and repair of tissue damage in plants and mammals.
AB - Innate immune receptors, well known mediators of response to non-self-molecules and inflammation, also act as mediators of immunity triggered by ‘damage-associated molecular patterns’ (DAMPs). Pathogen-associated molecular patterns (PAMPs) cause inflammation in mammals and a rapid immune response in plants, while DAMPs trigger more complex responses, including immunity, tissue maintenance and repair. DAMPs, their receptors and downstream transduction mechanisms are often conserved within a kingdom or, due to convergent evolution, are similar across the kingdoms of life. Herein, we describe the dynamics and functionality of specific extracellular DAMP classes and their receptors in immunity, inflammation and repair of tissue damage in plants and mammals.
KW - DAMPs
KW - extracellular matrix
KW - innate immunity
KW - pattern recognition receptors
UR - http://www.scopus.com/inward/record.url?scp=85054193151&partnerID=8YFLogxK
U2 - 10.1016/j.it.2018.09.006
DO - 10.1016/j.it.2018.09.006
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C2 - 30293747
SN - 1471-4906
VL - 39
SP - 937
EP - 950
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -