Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia

Laura Breda; Sara Gardenghi; Ella Guy; Eliezer A. Rachmilewitz; Orly Weizer-Stern; Konstantin Adamsky; Ninette Amariglio; Gideon Rechavi; Patricia J. Giardina; Robert W. Grady; Stefano Rivella

doi:10.1196/annals.1345.069

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia

Laura Breda, Sara Gardenghi, Ella Guy, Eliezer A. Rachmilewitz, Orly Weizer-Stern, Konstantin Adamsky, Ninette Amariglio, Gideon Rechavi, Patricia J. Giardina, Robert W. Grady, Stefano Rivella

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

To develop new treatments for β-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream. In mice, iron overload leads to overespression of Hamp, while Hamp-knockout mice suffer from hemochromatosis. The aim of this study is to investigate Hamp in the mouse model of β-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.

Original language	English
Pages (from-to)	417-422
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1054
DOIs	https://doi.org/10.1196/annals.1345.069
State	Published - 2005
Externally published	Yes

Keywords

Gene expression
Hamp
Iron overload
Lentivirus
β-thalassemia

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10.1196/annals.1345.069

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Breda, L., Gardenghi, S., Guy, E., Rachmilewitz, E. A., Weizer-Stern, O., Adamsky, K., Amariglio, N., Rechavi, G., Giardina, P. J., Grady, R. W., & Rivella, S. (2005). Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia. Annals of the New York Academy of Sciences, 1054, 417-422. https://doi.org/10.1196/annals.1345.069

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title = "Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia",

abstract = "To develop new treatments for β-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream. In mice, iron overload leads to overespression of Hamp, while Hamp-knockout mice suffer from hemochromatosis. The aim of this study is to investigate Hamp in the mouse model of β-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.",

keywords = "Gene expression, Hamp, Iron overload, Lentivirus, β-thalassemia",

author = "Laura Breda and Sara Gardenghi and Ella Guy and Rachmilewitz, {Eliezer A.} and Orly Weizer-Stern and Konstantin Adamsky and Ninette Amariglio and Gideon Rechavi and Giardina, {Patricia J.} and Grady, {Robert W.} and Stefano Rivella",

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doi = "10.1196/annals.1345.069",

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Breda, L, Gardenghi, S, Guy, E, Rachmilewitz, EA, Weizer-Stern, O, Adamsky, K, Amariglio, N, Rechavi, G, Giardina, PJ, Grady, RW & Rivella, S 2005, 'Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia', Annals of the New York Academy of Sciences, vol. 1054, pp. 417-422. https://doi.org/10.1196/annals.1345.069

TY - JOUR

T1 - Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia

AU - Breda, Laura

AU - Gardenghi, Sara

AU - Guy, Ella

AU - Rachmilewitz, Eliezer A.

AU - Weizer-Stern, Orly

AU - Adamsky, Konstantin

AU - Amariglio, Ninette

AU - Rechavi, Gideon

AU - Giardina, Patricia J.

AU - Grady, Robert W.

AU - Rivella, Stefano

PY - 2005

Y1 - 2005

N2 - To develop new treatments for β-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream. In mice, iron overload leads to overespression of Hamp, while Hamp-knockout mice suffer from hemochromatosis. The aim of this study is to investigate Hamp in the mouse model of β-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.

AB - To develop new treatments for β-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream. In mice, iron overload leads to overespression of Hamp, while Hamp-knockout mice suffer from hemochromatosis. The aim of this study is to investigate Hamp in the mouse model of β-thalassemia and to address the potential gene transfer of Hamp to prevent abnormal iron absorption.

KW - Gene expression

KW - Hamp

KW - Iron overload

KW - Lentivirus

KW - β-thalassemia

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Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in β-thalassemia

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Keywords

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