Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2-hydroxy-1-naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

Mahak Dalal, Jai Devi, Nidhi Antil, Binesh Kumar, Yogesh Kumar Verma, Subodh Kumar, Mukhan Wati, Sapana Garg

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4 Scopus citations

Abstract

In this study, Schiff base ligand 1,1′-((propane-1,3-diylbis [azaneylylidene]) bis (methaneylylidene))bis (naphthalen-2-ol) based Organyltellurium (IV) complexes were synthesized with formulae C32H27ClN2O3Te (5a)\C31H25ClN2O3Te (5b)\C32H27ClN2O3Te (5c)\ C39H34N2O4Te (5d)\ C37H30N2O4Te (5e)\ C39H34N2O4Te (5f) for acquiring a potential therapeutic agent. The synthesized compounds were characterized by ultraviolet–visible (UV–Vis), FT-IR, 1H-NMR, 13C-NMR, mass spectrometry, molar conductance, elemental analysis, powder X-ray diffraction and EDAX, which states that the tetradentate Schiff base ligand (HNDP) coordinated via oxygen and nitrogen atom with tellurium giving hexa-coordinated tellurium (IV) complexes. The thermal features of the ligand and complexes were studied using thermal (TGA and DTG) technique. The biochemical behavior of the Schiff base and its complexes was assessed by examining their reactivity against various microbial strains, DPPH free radicals as well as normal and cancer cells. The complex 5c exhibited the highest inhibition activity against bacterial strains while complex 5f showed the strongest inhibition activity against fungal strains. Complexes 5e and 5f displayed the most effective suppression of DPPH free radicals. The results of in vitro cytotoxicity study revealed that complex 5a demonstrated moderate cytotoxic effect on the L929 cell lines. Complex 5c displayed a significant cytotoxic effect on the PC3 cell line. Moreover, complex 5a, 5c and 5e exhibited the best cytotoxic activity against the Saos-2 cell line. Additionally, the structural forms of synthesized compounds were elucidated by DFT study. Furthermore, pharmacokinetic ADMET properties were estimated for their drug similarity behavior. The results advocate that complexes can be utilized as biological drugs.

Original languageEnglish
Article numbere7338
JournalApplied Organometallic Chemistry
Volume38
Issue number2
DOIs
StatePublished - Feb 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 John Wiley & Sons Ltd.

Funding

Ms. Mahak Dalal expresses her sincere gratitude to University Grants Commission (UGC), New Delhi and Maharshi Dayanand University, Rohtak for providing research facilities.

FundersFunder number
University Grants Commission
Maharishi Dayanand University

    Keywords

    • ADMET
    • DFT
    • Organyltellurium
    • Schiff base
    • cytotoxicity

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