TY - GEN
T1 - Exploring single-molecule SERS and single-nanoparticle plasmon microscopy
AU - Wustholz, Kristin L.
AU - Henry, Anne Isabelle
AU - Bingham, Julia M.
AU - Kleinman, Samuel L.
AU - Natan, Michael J.
AU - Freeman, R. Griffith
AU - Van Duyne, Richard P.
PY - 2009
Y1 - 2009
N2 - In this work we perform correlated structural and optical studies of single nanoparticles as well as explore the generality of SMSERS. First, wide-field plasmon resonance microscopy is used to simultaneously determine the LSPR spectra of multiple Ag nanoprisms, whose structure is determined using TEM. Next, the structure-property relationships for well-defined and easily-controlled nanoparticle structures (e.g. monomers, dimers, and trimers) are studied using correlated TEM, LSPR, and SERS measurements of individual SERS nanotags. We present the SER spectrum of reporter molecules on a single nanotag comprised of a Au trimer. It was determined that of 40 individual nanotags, just 19 exhibited SERS. The remaining nanoparticles were established by TEM to be monomers. These results demonstrate that SERS signal is observed from individual nanotags containing a junction or hot spot. Lastly, we explore crystal violet, a triphenyl methane dye that was used in the seminal SMSERS investigations, and re-examine single-molecule sensitivity using the isotopologue approach.
AB - In this work we perform correlated structural and optical studies of single nanoparticles as well as explore the generality of SMSERS. First, wide-field plasmon resonance microscopy is used to simultaneously determine the LSPR spectra of multiple Ag nanoprisms, whose structure is determined using TEM. Next, the structure-property relationships for well-defined and easily-controlled nanoparticle structures (e.g. monomers, dimers, and trimers) are studied using correlated TEM, LSPR, and SERS measurements of individual SERS nanotags. We present the SER spectrum of reporter molecules on a single nanotag comprised of a Au trimer. It was determined that of 40 individual nanotags, just 19 exhibited SERS. The remaining nanoparticles were established by TEM to be monomers. These results demonstrate that SERS signal is observed from individual nanotags containing a junction or hot spot. Lastly, we explore crystal violet, a triphenyl methane dye that was used in the seminal SMSERS investigations, and re-examine single-molecule sensitivity using the isotopologue approach.
KW - Crystal violet
KW - LSPR imaging
KW - Localized surface plasmon resonance
KW - Nanoprisms
KW - SERS nanotags
KW - Single-nanoparticle spectroscopy
KW - Surface-enhanced Raman spectroscopy
KW - Transmission electron microscopy
KW - Wide-field imaging
UR - http://www.scopus.com/inward/record.url?scp=70449341755&partnerID=8YFLogxK
U2 - 10.1117/12.826168
DO - 10.1117/12.826168
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AN - SCOPUS:70449341755
SN - 9780819476845
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Plasmonics
T2 - Plasmonics: Metallic Nanostructures and Their Optical Properties VII
Y2 - 2 August 2009 through 6 August 2009
ER -