Exploring N6-methyladenosine (m6A) modification in tree species: opportunities and challenges

Muthusamy Ramakrishnan, K. Shanmugha Rajan, Sileesh Mullasseri, Zishan Ahmad, Mingbing Zhou, Anket Sharma, Subbiah Ramasamy, Qiang Wei

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

N6-methyladenosine (m6A) in eukaryotes is the most common and widespread internal modification in mRNA. The modification regulates mRNA stability, translation efficiency, and splicing, thereby fine-tuning gene regulation. In plants, m6A is dynamic and critical for various growth stages, embryonic development, morphogenesis, flowering, stress response, crop yield, and biomass. Although recent high-throughput sequencing approaches have enabled the rapid identification of m6A modification sites, the site-specific mechanism of this modification remains unclear in trees. In this review, we discuss the functional significance of m6A in trees under different stress conditions and discuss recent advancements in the quantification of m6A. Quantitative and functional insights into the dynamic aspect of m6A modification could assist researchers in engineering tree crops for better productivity and resistance to various stress conditions.

Original languageEnglish
Article numberuhad284
JournalHorticulture Research
Volume11
Issue number2
DOIs
StatePublished - 1 Feb 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of Nanjing Agricultural University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Funding

Preparation of this review was supported by a grant from the National Key Research & Development Program of China (2021YFD2200503-01), a grant from the National Natural Science Foundation of China (32071848), a grant from the Natural Science Foundation of Jiangsu Province (BK20231289), the Jiangxi ‘Shuangqian’ Program (S2019DQKJ2030), the Natural Science Foundation for Distinguished Young Scholars of Nanjing Forestry University (JC2019004), the Project for Groundbreaking Achievements of Nanjing Forestry University (202211), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. The authors are also grateful for the Young Foreign Talent Program (QN2022014012L) and the support of Metasequoia Faculty Research Start-up Funding (163100028) at the Bamboo Research Institute, Nanjing Forestry University, for the first author, M.R. K.S.R. is supported by the Dean of Faculty Fellowship, the Koshland Prize, and a Sir Charles Clore Postdoctoral Fellowship from the Weizmann Institute.

FundersFunder number
Bamboo Research Institute
Metasequoia Faculty Research Start-up Funding163100028
Natural Science Foundation for Distinguished Young Scholars of Nanjing Forestry UniversityJC2019004
Weizmann Institute
Young Foreign Talent ProgramQN2022014012L
Nanjing Forestry University202211
National Natural Science Foundation of China32071848
Natural Science Foundation of Jiangsu ProvinceBK20231289, S2019DQKJ2030
National Key Research and Development Program of China2021YFD2200503-01
Priority Academic Program Development of Jiangsu Higher Education Institutions

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