TY - JOUR
T1 - Exploring Localized Provoked Vulvodynia
T2 - Insights from Animal Model Research
AU - Nakhleh-Francis, Yara
AU - Awad-Igbaria, Yaseen
AU - Sakas, Reem
AU - Bang, Sarina
AU - Abu-Ata, Saher
AU - Palzur, Eilam
AU - Lowenstein, Lior
AU - Bornstein, Jacob
PY - 2024/4/11
Y1 - 2024/4/11
N2 - Provoked vulvodynia represents a challenging chronic pain condition, characterized by its multifactorial origins. The inherent complexities of human-based studies have necessitated the use of animal models to enrich our understanding of vulvodynia's pathophysiology. This review aims to provide an exhaustive examination of the various animal models employed in this research domain. A comprehensive search was conducted on PubMed, utilizing keywords such as "vulvodynia", "chronic vulvar pain", "vulvodynia induction", and "animal models of vulvodynia" to identify pertinent studies. The search yielded three primary animal models for vulvodynia: inflammation-induced, allergy-induced, and hormone-induced. Additionally, six agents capable of triggering the condition through diverse pathways were identified, including factors contributing to hyperinnervation, mast cell proliferation, involvement of other immune cells, inflammatory cytokines, and neurotransmitters. This review systematically outlines the various animal models developed to study the pathogenesis of provoked vulvodynia. Understanding these models is crucial for the exploration of preventative measures, the development of novel treatments, and the overall advancement of research within the field.
AB - Provoked vulvodynia represents a challenging chronic pain condition, characterized by its multifactorial origins. The inherent complexities of human-based studies have necessitated the use of animal models to enrich our understanding of vulvodynia's pathophysiology. This review aims to provide an exhaustive examination of the various animal models employed in this research domain. A comprehensive search was conducted on PubMed, utilizing keywords such as "vulvodynia", "chronic vulvar pain", "vulvodynia induction", and "animal models of vulvodynia" to identify pertinent studies. The search yielded three primary animal models for vulvodynia: inflammation-induced, allergy-induced, and hormone-induced. Additionally, six agents capable of triggering the condition through diverse pathways were identified, including factors contributing to hyperinnervation, mast cell proliferation, involvement of other immune cells, inflammatory cytokines, and neurotransmitters. This review systematically outlines the various animal models developed to study the pathogenesis of provoked vulvodynia. Understanding these models is crucial for the exploration of preventative measures, the development of novel treatments, and the overall advancement of research within the field.
KW - Localized Provoked Vulvodynia (LPV)
KW - animal model of vulvodynia
KW - chronic vulvar pain
KW - hyperinnervation
KW - vulvodynia
KW - vulvodynia induction
UR - http://www.scopus.com/inward/record.url?scp=85191621044&partnerID=8YFLogxK
U2 - 10.3390/ijms25084261
DO - 10.3390/ijms25084261
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C2 - 38673846
AN - SCOPUS:85191621044
SN - 1661-6596
VL - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 8
ER -