TY - JOUR
T1 - Expert Consensus on Prevention and Treatment of Aging-Related Gonadal Dysfunction
AU - Wang, Xi
AU - Ma, Li
AU - Jiang, Sheng
AU - Wen, Junping
AU - Yan, Zhaoli
AU - Tian, Long
AU - Deng, Shan
AU - Huang, Boxian
AU - Stambler, Ilia
AU - Caruso, Calogero
AU - Min, Kyung Jin
AU - Su, Huanxing
AU - Jin, Kunlin
AU - Mao, Jiangfeng
AU - Wu, Xueyan
AU - Han, Qin
AU - Zhao, Robert Chunhua
N1 - Publisher Copyright:
© 2024 Guo L. et al.
PY - 2024/4/10
Y1 - 2024/4/10
N2 - Aging-related hypogonadism involves complex mechanisms in humans, predominantly relating to the decline of multiple hormones and senile gonads. Late-onset hypogonadism (LOH) and erectile dysfunction (ED) are the main manifestations in men, while premature ovarian insufficiency (POI) and menopause are the main forms in women. Anti-aging measures include lifestyle modification and resistance training, hormonal supplementation, stem cell therapy, metformin, and rapamycin. In this expert consensus, the mechanisms, efficacy, and side effects of stem cell therapy on aging gonadal function are reviewed. Furthermore, various methods of stem cell therapy, administered intravenously, intracavernously, and intra-ovarially, are exemplified in detail. More clinical trials on aging-related gonadal dysfunction are required to solidify the foundation of this topic.
AB - Aging-related hypogonadism involves complex mechanisms in humans, predominantly relating to the decline of multiple hormones and senile gonads. Late-onset hypogonadism (LOH) and erectile dysfunction (ED) are the main manifestations in men, while premature ovarian insufficiency (POI) and menopause are the main forms in women. Anti-aging measures include lifestyle modification and resistance training, hormonal supplementation, stem cell therapy, metformin, and rapamycin. In this expert consensus, the mechanisms, efficacy, and side effects of stem cell therapy on aging gonadal function are reviewed. Furthermore, various methods of stem cell therapy, administered intravenously, intracavernously, and intra-ovarially, are exemplified in detail. More clinical trials on aging-related gonadal dysfunction are required to solidify the foundation of this topic.
KW - anti-aging
KW - erectile dysfunction
KW - late-onset hypogonadism
KW - menopause
KW - premature ovarian insufficiency
KW - stem cell therapy
UR - http://www.scopus.com/inward/record.url?scp=105001973571&partnerID=8YFLogxK
U2 - 10.14336/ad.2024.0004
DO - 10.14336/ad.2024.0004
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C2 - 38739936
AN - SCOPUS:105001973571
SN - 2152-5250
VL - 16
SP - 971
EP - 979
JO - Aging and Disease
JF - Aging and Disease
IS - 2
ER -