Exacerbation of Wegener's granulomatosis during pregnancy: Report of a case with tracheal stenosis and literature review

H. Pauzner, H. Mayan, E. Hershko, M. Alcalay, Z. Farfel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Wegener's granulomatosis (WG) is a rare multisystem disease of unknown etiology. We describe a woman with WG who relapsed twice during 2 pregnancies with appearance of tracheal stenosis. During the first pregnancy which ended with a delivery of a healthy baby, the subglottic stenosis responded to laser radiation and glucocorticosteroid therapy. An uneventful therapeutic abortion was performed during the 2nd pregnancy. Our case brings to 15 the number of pregnancies which were recorded in 10 women with WG. Diagnosis of WG was done during pregnancy in 4 cases, and at the postpartum period in 3 cases. Eight pregnancies occurred in women with known WG, relapse occurred in 5 pregnancies. Two cases ended with maternal death. It seems therefore that pregnancy may have a significant contribution both to the relapse of WG and to its appearance.

Original languageEnglish
Pages (from-to)1153-1156
Number of pages4
JournalJournal of Rheumatology
Volume21
Issue number6
StatePublished - Jun 1994
Externally publishedYes

Keywords

  • Pregnancy
  • Tracheal stenosis
  • Wegener's granulomatosis

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