Evolutionary Modeling of Protein Families by Chromosomal Translocation Events

Gon Carmi, Alessandro Gorohovski, Milana Frenkel-Morgenstern

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter introduces a novel model, “evolution of protein domains” (EvoProDom), to describe the evolution of proteins. The model is based on exchange of protein domains in a “mix and merge” manner. Initially, a full description of the model was included with and its application to a collection of 109 organisms with full genomic and proteome data, including protein domain content and orthologous protein annotation predicted from sequences. The chapter mainly focuses on translocations of protein domains, that is reciprocal exchanges between orthologous proteins of diverse organisms. It presents data that shows enrichment of translocation events in trans-splicing events, which is producing novel transcripts fused from two different genes.

Original languageEnglish
Title of host publicationNew Horizons in Evolution
Number of pages34
ISBN (Electronic)9780323907521
StatePublished - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.


  • Protein domains
  • Protein evolution
  • Translocations


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